Homobimetallic organotin(IV) complexes with hexadentate Schiff base: Synthesis, crystal structure and antimicrobial studies

This article describes the synthesis of four new homobimetallic organotin(IV) complexes: [Et2Sn](2)L (1), [Bu2Sn](2)L (2), [Oct(2)Sn](2)L (3) and [BuClSn](2)L (4) (H4L = N-1 ', N-6 '-bis(5-bromo-2- hydroxybenzylidene)adipodihydrazide) and their structural elucidation by means of elemental analysis, mass spectroscopy, FT- IR, NMR (H-1, C-13, Sn-119) and single crystal X-ray analysis. Spectroscopic studies indicate coordination of hexadentate ligand to the diorganotin(IV) moieties via ONO-ONO donor sites and pentacoordinated tin centers. Single crystal X-ray analysis of (1) and (2) revealed homobimetallic nature of complexes with each Sn atom in a distorted square pyramidal coordination geometry. Packing diagrams suggest the seminal role of Sn...N and Br...pi interactions in generating supramolecular assembly. The synthesized compounds were screened for their antimicrobial activity and cytotoxicity. Compound (2) exhibit highest activity against several pathogenic microbes. (C) 2014 Elsevier B.V. All rights reserved.