The temporal resolution of quantitative phase imaging with Differential Phase Contrast (DPC) is limited by the requirement for multiple illumination-encoded measurements. This inhibits imaging of fast-moving samples. We present a computational approach to model and correct for non-rigid sample motion during the DPC acquisition in order to improve temporal resolution to that of a single-shot method and enable imaging of motion dynamics at the framerate of the sensor. Our method relies on the addition of a simultaneously-acquired color-multiplexed reference signal to enable non-rigid registration of measurements prior to phase retrieval. We show experimental results where we reduce motion blur from fast-moving live biological samples. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USA
Han, Fei
Zhou, Ziwu
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Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Bioengn, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USA
Zhou, Ziwu
Cao, Minsong
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Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiat Oncol, 200 UCLA Med Plaza Suite B265, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, David Geffen Sch Med, Phys & Biol Med Grad Program, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USA
Cao, Minsong
Yang, Yingli
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Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiat Oncol, 200 UCLA Med Plaza Suite B265, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, David Geffen Sch Med, Phys & Biol Med Grad Program, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USA
Yang, Yingli
Sheng, Ke
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Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiat Oncol, 200 UCLA Med Plaza Suite B265, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, David Geffen Sch Med, Phys & Biol Med Grad Program, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USA
Sheng, Ke
Hu, Peng
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Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, David Geffen Sch Med, Phys & Biol Med Grad Program, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, 300 UCLA Med Plaza Suite B119, Los Angeles, CA 90095 USA
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Korea Adv Inst Sci & Technol, Dept Phys, Daejeon, South Korea
Korea Adv Inst Sci & Technol, Inst Hlth Sci & Technol, Daejeon, South Korea
Tomocube Inc, Daejeon, South KoreaKorea Adv Inst Sci & Technol, Dept Phys, Daejeon, South Korea
Park, YongKeun
Depeursinge, Christian
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Ecole Polytech Fed Lausanne, Microvis & Microdiagnost Grp SCI STI CHD, Lausanne, Switzerland
KAUST, Lab Cellular Imaging & Energet, Biol & Environm Sci & Engn Div, Thuwal, Saudi ArabiaKorea Adv Inst Sci & Technol, Dept Phys, Daejeon, South Korea
Depeursinge, Christian
Popescu, Gabriel
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Univ Illinois, Beckman Inst Adv Sci & Technol, Dept Elect & Comp Engn, Urbana, IL 61801 USA
Univ Illinois, Beckman Inst Adv Sci & Technol, Dept Bioengn, Urbana, IL 61801 USAKorea Adv Inst Sci & Technol, Dept Phys, Daejeon, South Korea