Concordance of Clinical Alzheimer Diagnosis and Neuropathological Features at Autopsy

被引：26
|
作者：
Gauthreaux, Kathryn [1 ]
Bonnett, Tyler A. [2 ]
Besser, Lilah M. [3 ]
Brenowitz, Willa D. [4 ]
Teylan, Merilee [1 ]
Mock, Charles [1 ]
Chen, Yen-Chi [5 ]
Chan, Kwun C. G. [1 ]
Keene, C. Dirk [6 ]
Zhou, Xiao-Hua [1 ]
Kukull, Walter A. [1 ]
机构：
[1] Univ Washington, Dept Epidemiol, Natl Alzheimers Coordinating Ctr, Seattle, WA 98105 USA
[2] NCI, Clin Monitoring Res Program Directorate, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA
[3] Florida Atlantic Univ, Sch Urban & Reg Planning, Inst Human Hlth & Dis Intervent, Boca Raton, FL 33431 USA
[4] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
[5] Univ Washington, Dept Stat, Seattle, WA 98105 USA
[6] Univ Washington, Dept Pathol, Seattle, WA 98105 USA
来源：
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2020年 / 79卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Alzheimer disease; Diagnosis; Neuropathology; AGE-RELATED TAUOPATHY; NATIONAL INSTITUTE; ASSOCIATION WORKGROUPS; LEWY BODIES; DISEASE; GUIDELINES; DEMENTIA; RECOMMENDATIONS; MANAGEMENT;
D O I：
10.1093/jnen/nlaa014
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
It remains unclear what clinical features inform the accuracy of a clinical diagnosis of Alzheimer disease (AD). Data were obtained from the National Alzheimer's Coordinating Center to compare clinical and neuropathologic features among participants who did or did not have Alzheimer disease neuropathologic changes (ADNC) at autopsy. Participants (1854) had a clinical Alzheimer dementia diagnosis and ADNC at autopsy (Confirmed-AD), 204 participants had an AD diagnosis and no ADNC (AD-Mimics), and 253 participants had no AD diagnosis and ADNC (Unidentified-AD). Compared to Confirmed-AD participants, AD-Mimics had less severe cognitive impairment, while Unidentified-AD participants displayed more parkinsonian signs, depression, and behavioral problems. This study highlights the importance of developing a complete panel of biomarkers as a tool to inform clinical diagnoses, as clinical phenotypes that are typically associated with diseases other than AD may result in inaccurate diagnoses.
引用
收藏
页码：465 / 473
页数：9
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