Concordance of Clinical Alzheimer Diagnosis and Neuropathological Features at Autopsy

被引：26
|
作者：
Gauthreaux, Kathryn [1 ]
Bonnett, Tyler A. [2 ]
Besser, Lilah M. [3 ]
Brenowitz, Willa D. [4 ]
Teylan, Merilee [1 ]
Mock, Charles [1 ]
Chen, Yen-Chi [5 ]
Chan, Kwun C. G. [1 ]
Keene, C. Dirk [6 ]
Zhou, Xiao-Hua [1 ]
Kukull, Walter A. [1 ]
机构：
[1] Univ Washington, Dept Epidemiol, Natl Alzheimers Coordinating Ctr, Seattle, WA 98105 USA
[2] NCI, Clin Monitoring Res Program Directorate, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA
[3] Florida Atlantic Univ, Sch Urban & Reg Planning, Inst Human Hlth & Dis Intervent, Boca Raton, FL 33431 USA
[4] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
[5] Univ Washington, Dept Stat, Seattle, WA 98105 USA
[6] Univ Washington, Dept Pathol, Seattle, WA 98105 USA
来源：
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2020年 / 79卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Alzheimer disease; Diagnosis; Neuropathology; AGE-RELATED TAUOPATHY; NATIONAL INSTITUTE; ASSOCIATION WORKGROUPS; LEWY BODIES; DISEASE; GUIDELINES; DEMENTIA; RECOMMENDATIONS; MANAGEMENT;
D O I：
10.1093/jnen/nlaa014
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
It remains unclear what clinical features inform the accuracy of a clinical diagnosis of Alzheimer disease (AD). Data were obtained from the National Alzheimer's Coordinating Center to compare clinical and neuropathologic features among participants who did or did not have Alzheimer disease neuropathologic changes (ADNC) at autopsy. Participants (1854) had a clinical Alzheimer dementia diagnosis and ADNC at autopsy (Confirmed-AD), 204 participants had an AD diagnosis and no ADNC (AD-Mimics), and 253 participants had no AD diagnosis and ADNC (Unidentified-AD). Compared to Confirmed-AD participants, AD-Mimics had less severe cognitive impairment, while Unidentified-AD participants displayed more parkinsonian signs, depression, and behavioral problems. This study highlights the importance of developing a complete panel of biomarkers as a tool to inform clinical diagnoses, as clinical phenotypes that are typically associated with diseases other than AD may result in inaccurate diagnoses.
引用
收藏
页码：465 / 473
页数：9
相关论文
共 50 条
  • [31] Quantification of neuropathological findings by image data for the diagnosis of dementia in forensic autopsy cases
    Takayama, Mio
    Kashiwagi, Masayuki
    Matsusue, Aya
    Waters, Brian
    Hara, Kenji
    Ikematsu, Natsuki
    Kubo, Shin-ichi
    JOURNAL OF MEDICAL INVESTIGATION, 2016, 63 (1-2): : 114 - 118
  • [32] Strategies for improving the postmortem neuropathological diagnosis of Alzheimer's disease
    Trojanowski, JQ
    Clark, CM
    Schmidt, ML
    Arnold, SE
    Lee, VMY
    NEUROBIOLOGY OF AGING, 1997, 18 (04) : S75 - S79
  • [33] Coexistence of CJD and Alzheimer's disease: An autopsy case showing typical clinical features of CJD
    Tsuchiya, K
    Yagishita, S
    Ikeda, K
    Sano, M
    Taki, K
    Hashimoto, K
    Watabiki, S
    Mizusawa, H
    NEUROPATHOLOGY, 2004, 24 (01) : 46 - 55
  • [34] Acute demyelination, neuropathological diagnosis, and clinical evolution
    Annesley-Williams, D
    Farrell, MA
    Staunton, H
    Brett, FM
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2000, 59 (06): : 477 - 489
  • [35] Do we still need the autopsy? Clinical diagnosis versus autopsy diagnosis
    Ioan, Beatrice
    Alexa, Teodora
    Alexa, Ioana-Dana
    ROMANIAN JOURNAL OF LEGAL MEDICINE, 2012, 20 (04): : 307 - 312
  • [36] INFANTILE NEUROAXONAL DYSTROPHY - CLINICAL AND NEUROPATHOLOGICAL DIAGNOSIS
    SANGALANG, V
    CAMFIELD, P
    TIBBLES, JAR
    CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1979, 6 (03) : 389 - 389
  • [37] Histopathological Analysis of Cerebral Microvasculature Pathology with Alzheimer's Disease Neuropathological Changes: An Autopsy Study
    Cao, Yuan
    Huang, Mei-Ying
    Mao, Chen-Hui
    Wang, Xue
    Xu, Yuan-Yuan
    Qian, Xiao-Jing
    Ma, Chao
    Qiu, Wen-Ying
    Zhu, Yi-Cheng
    NEUROLOGY, 2023, 100 (17)
  • [38] Rapidly progressive Alzheimer's disease and sporadic Creutzfeldt-Jakob disease: comparison of clinical and neuropathological features
    Krbot, K.
    Hermann, P.
    Krbot-Skoric, M.
    Zerr, I.
    Krasemann, S.
    Sepulveda-Falla, D.
    Matschke, J.
    Glatzel, M.
    EUROPEAN JOURNAL OF NEUROLOGY, 2018, 25 : 378 - 379
  • [39] Prediction of Autopsy Verified Neuropathological Change of Alzheimer's Disease Using Machine Learning and MRI
    Kautzky, Alexander
    Seiger, Rene
    Hahn, Andreas
    Fischer, Peter
    Krampla, Wolfgang
    Kasper, Siegfried
    Kovacs, Gabor G.
    Lanzenberger, Rupert
    FRONTIERS IN AGING NEUROSCIENCE, 2018, 10
  • [40] Current Status and Future Perspective of Seoul National University Hospital-Dementia Brain Bank with Concordance of Clinical and Neuropathological Diagnosis
    Lee, Kwanghoon
    Kim, Seong-Ik
    Shim, Yu-Mi
    Kim, Eric Enshik
    Yoo, Sooyeon
    Won, Jae-Kyung
    Park, Sung-Hye
    EXPERIMENTAL NEUROBIOLOGY, 2024, 33 (06) : 295 - 311
12345