Tyrosinase Inhibitors from the Stems of Streblus Ilicifolius

被引：3
|
作者：
Nguyen, Nhan T. [1 ,2 ,3 ]
Dang, Phu H. [1 ,2 ]
Nguyen, Hai X. [1 ,2 ]
Do, Truong N., V [1 ,2 ]
Le, Tho H. [1 ,2 ]
Le, Tuyen Q. H. [1 ,2 ]
Nguyen, Mai T. T. [1 ,2 ,3 ]
机构：
[1] Univ Sci, Fac Chem, 227 Nguyen Van Cu St,Ward 4,Dist 5, Ho Chi Minh City, Vietnam
[2] Vietnam Natl Univ, Linh Trung Ward, Quarter 6, Ho Chi Minh City, Vietnam
[3] Univ Sci, Canc Res Lab, 227 Nguyen Van Cu St,Dist 5, Ho Chi Minh City, Vietnam
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2021年 / 2021卷
关键词：
D O I：
10.1155/2021/5561176
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Two new stilbene derivatives, named strebluses C and D, were isolated from the EtOAc-soluble fraction of the stems of Streblus ilicifolius (Moraceae). Its absolute configuration was elucidated based on NMR spectroscopic data interpretation and optical rotation calculation. Streblus C possesses strong tyrosinase inhibitory activity with an IC50 value of 0.01 mu M. Docking studies of 1 and 2 with oxy-tyrosinase were carried out to analyze their interactions. The analysis of the docked poses confirmed that 1 showed better binding affinity for oxy-tyrosinase than that of 2.
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页数：7
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