Poly(-glutamic acid), coagulation? Anticoagulation?

被引：7
|
作者：
Xu, Tingting [1 ,2 ]
Peng, Fang [2 ]
Zhang, Tao [2 ]
Chi, Bo [1 ]
Xu, Hong [1 ]
Mao, Chun [2 ]
Feng, Shuaihui [2 ]
机构：
[1] Nanjing Tech Univ, Coll Food Sci & Light Ind, State Key Lab Mat Oriented Chem Engn, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Normal Univ, Sch Chem & Mat Sci, Natl & Local Joint Engn Res Ctr Biomed Funct Mat, Jiangsu Key Lab Biofunct Mat, Nanjing, Jiangsu, Peoples R China
来源：
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2016年 / 27卷 / 16期
基金：
中国国家自然科学基金;
关键词：
Poly(-glutamic acid); water-absorption; coagulation; anticoagulation; cytotoxicity; GAMMA-GLUTAMIC ACID; POLY(GAMMA-GLUTAMIC ACID); IN-VITRO; BIOLOGICAL EVALUATION; BLOOD-COAGULATION; POLYGLUTAMIC ACID; MOLECULAR-WEIGHT; NANOPARTICLES; MEMBRANES; HEMOCOMPATIBILITY;
D O I：
10.1080/09205063.2016.1221700
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Poly(-glutamic acid) (-PGA) powder was usually used as hemostatic agent because of its excellent physical properties of water-absorption and water-locking. However, if -PGA absorbs enough water, how about its blood compatibility? Here, the other side of the coin was investigated. The anticoagulant properties of -PGA were characterized by in vitro coagulation tests, hemolytic assay, platelet adhesion, and platelet activation. Moreover, cytotoxicity experiments of -PGA were also carried out by MTT assay. Results indicated that the sufficient water-absorbed -PGA has good anticoagulant property and non-cytotoxicity. It means -PGA has good anticoagulant property, non-cytotoxicity. If -PGA has absorbed enough water, it can be used as an anticoagulation biomaterial. With double effects (coagulation and anticoagulation), the -PGA with desirable bioproperties can be readily tailored to cater to various biomedical applications.
引用
收藏
页码：1599 / 1610
页数：12
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