Poly(-glutamic acid), coagulation? Anticoagulation?

被引：7

作者：

Xu, Tingting ^{[1
,2
]}

Peng, Fang ^{[2
]}

Zhang, Tao ^{[2
]}

Chi, Bo ^{[1
]}

Xu, Hong ^{[1
]}

Mao, Chun ^{[2
]}

Feng, Shuaihui ^{[2
]}

机构：

[1] Nanjing Tech Univ, Coll Food Sci & Light Ind, State Key Lab Mat Oriented Chem Engn, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Normal Univ, Sch Chem & Mat Sci, Natl & Local Joint Engn Res Ctr Biomed Funct Mat, Jiangsu Key Lab Biofunct Mat, Nanjing, Jiangsu, Peoples R China

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2016年 / 27卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Poly(-glutamic acid); water-absorption; coagulation; anticoagulation; cytotoxicity; GAMMA-GLUTAMIC ACID; POLY(GAMMA-GLUTAMIC ACID); IN-VITRO; BIOLOGICAL EVALUATION; BLOOD-COAGULATION; POLYGLUTAMIC ACID; MOLECULAR-WEIGHT; NANOPARTICLES; MEMBRANES; HEMOCOMPATIBILITY;

D O I：

10.1080/09205063.2016.1221700

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Poly(-glutamic acid) (-PGA) powder was usually used as hemostatic agent because of its excellent physical properties of water-absorption and water-locking. However, if -PGA absorbs enough water, how about its blood compatibility? Here, the other side of the coin was investigated. The anticoagulant properties of -PGA were characterized by in vitro coagulation tests, hemolytic assay, platelet adhesion, and platelet activation. Moreover, cytotoxicity experiments of -PGA were also carried out by MTT assay. Results indicated that the sufficient water-absorbed -PGA has good anticoagulant property and non-cytotoxicity. It means -PGA has good anticoagulant property, non-cytotoxicity. If -PGA has absorbed enough water, it can be used as an anticoagulation biomaterial. With double effects (coagulation and anticoagulation), the -PGA with desirable bioproperties can be readily tailored to cater to various biomedical applications.

引用

页码：1599 / 1610

页数：12

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