Aquilanols A and B, Macrocyclic Humulene-Type Sesquiterpenoids from the Agarwood of Aquilaria malaccensis

被引：33

作者：

Chi Thanh Ma ^{[1
,5
]}

Eom, Taeyong ^{[4
]}

Cho, Eunji ^{[2
]}

Wu, Bo ^{[3
]}

Kim, Tae Ryong ^{[1
]}

Oh, Ki Bong ^{[2
]}

Han, Sang Beom ^{[4
]}

Kwon, Sung Won ^{[1
]}

Park, Jeong Hill ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Agr & Life Sci, Coll Pharm, Seoul 08826, South Korea

[2] Seoul Natl Univ, Coll Agr & Life Sci, Dept Agr Biotechnol, Seoul 08826, South Korea

[3] China Med Univ, Dept Chem, Shenyang 110122, Liaoning, Peoples R China

[4] Chung Ang Univ, Coll Pharm, Seoul 06974, South Korea

[5] Univ Med & Pharm, Fac Pharm, Ho Chi Minh City 700000, Vietnam

来源：

JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

2-(2-PHENYLETHYL)CHROMONE DERIVATIVES; =2-(2-PHENYLETHYL)-4H-1-BENZOPYRAN-4-ONE DERIVATIVES; CHINESE;

D O I：

10.1021/acs.jnatprod.7b00462

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new and five known sesquiterpenoids were isolated from the agarwood of Aquilaria malaccensis. Aquilanols A and B (1 and 2) have an unprecedented macrocyclic humulene structure with a bicyclic 7/10 ring system. Compound 2 was obtained as a scalemic mixture that was resolved by HPLC analysis using a chiral column. Their structures were deduced based on spectroscopic data analysis, and the absolute configurations were unambiguously determined by X-ray crystallographic data and ECD spectroscopic analysis. A putative biosynthetic pathway of these sesquiterpenoids is proposed.

引用

页码：3043 / 3048

页数：6

共 43 条

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