Aquilanols A and B, Macrocyclic Humulene-Type Sesquiterpenoids from the Agarwood of Aquilaria malaccensis

被引：33
|
作者：
Chi Thanh Ma [1 ,5 ]
Eom, Taeyong [4 ]
Cho, Eunji [2 ]
Wu, Bo [3 ]
Kim, Tae Ryong [1 ]
Oh, Ki Bong [2 ]
Han, Sang Beom [4 ]
Kwon, Sung Won [1 ]
Park, Jeong Hill [1 ]
机构：
[1] Seoul Natl Univ, Coll Agr & Life Sci, Coll Pharm, Seoul 08826, South Korea
[2] Seoul Natl Univ, Coll Agr & Life Sci, Dept Agr Biotechnol, Seoul 08826, South Korea
[3] China Med Univ, Dept Chem, Shenyang 110122, Liaoning, Peoples R China
[4] Chung Ang Univ, Coll Pharm, Seoul 06974, South Korea
[5] Univ Med & Pharm, Fac Pharm, Ho Chi Minh City 700000, Vietnam
来源：
JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 11期
基金：
新加坡国家研究基金会;
关键词：
2-(2-PHENYLETHYL)CHROMONE DERIVATIVES; =2-(2-PHENYLETHYL)-4H-1-BENZOPYRAN-4-ONE DERIVATIVES; CHINESE;
D O I：
10.1021/acs.jnatprod.7b00462
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four new and five known sesquiterpenoids were isolated from the agarwood of Aquilaria malaccensis. Aquilanols A and B (1 and 2) have an unprecedented macrocyclic humulene structure with a bicyclic 7/10 ring system. Compound 2 was obtained as a scalemic mixture that was resolved by HPLC analysis using a chiral column. Their structures were deduced based on spectroscopic data analysis, and the absolute configurations were unambiguously determined by X-ray crystallographic data and ECD spectroscopic analysis. A putative biosynthetic pathway of these sesquiterpenoids is proposed.
引用
收藏
页码：3043 / 3048
页数：6
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