Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats

被引：3

作者：

Sever'yanova, L. A. ^{[1
]}

Dolgintsev, M. E. ^{[1
]}

机构：

[1] Kursk State Med Univ, Dept Pathophysiol, Kursk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 164卷 / 02期

关键词：

regulatory peptides; pain; aggressive-defensive behavior; amino acids; MECHANISMS;

D O I：

10.1007/s10517-017-3943-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effect of Gly-His -Lys tripeptide administered intraperitoneally in doses of 5, 15, 50 and 150 mu g/kg on pain-induced aggressive-defensive behavior. A foot-shock model of aggression in rats grouped in pairs in an electrified chamber was used. Analgesic and antiaggresiogenic effects of the peptide were demonstrated. It was found the L-lysine residue plays the key role in these effects, because they were observed under the influence of L-lysine administration in doses close to its equimolar content in the studied tripeptide.

引用

页码：140 / 143

页数：4

共 35 条

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