Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats

被引：3
|
作者：
Sever'yanova, L. A. [1 ]
Dolgintsev, M. E. [1 ]
机构：
[1] Kursk State Med Univ, Dept Pathophysiol, Kursk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 164卷 / 02期
关键词：
regulatory peptides; pain; aggressive-defensive behavior; amino acids; MECHANISMS;
D O I：
10.1007/s10517-017-3943-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of Gly-His -Lys tripeptide administered intraperitoneally in doses of 5, 15, 50 and 150 mu g/kg on pain-induced aggressive-defensive behavior. A foot-shock model of aggression in rats grouped in pairs in an electrified chamber was used. Analgesic and antiaggresiogenic effects of the peptide were demonstrated. It was found the L-lysine residue plays the key role in these effects, because they were observed under the influence of L-lysine administration in doses close to its equimolar content in the studied tripeptide.
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页码：140 / 143
页数：4
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