Asymmetric Synthesis of Pipecolic Acid and Derivatives

被引：32

作者：

Cant, Alastair A. ^{[1
]}

Sutherland, Andrew ^{[1
]}

机构：

[1] Univ Glasgow, WestCHEM, Sch Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 13期

关键词：

amino acids; heterocycles; piperidines; asymmetric synthesis; asymmetric catalysis; CYCLIC AMINO-ACIDS; RING-CLOSING METATHESIS; DIASTEREOSELECTIVE SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; INTRAMOLECULAR REACTION; EFFICIENT SYNTHESIS; ENZYMATIC-SYNTHESIS; FORMAL SYNTHESIS; ASPARTIC-ACID;

D O I：

10.1055/s-0031-1289767

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The nonproteinogenic alpha-amino acid, L-pipecolic acid and its derivatives are components of a wide range of pharmacologically active compounds. The significant biological activity of these compounds has resulted in the development of many synthetic approaches for their preparation. This review highlights these key methods as well as the application of these compounds for the preparation of enzyme inhibitors, conformationally restricted building blocks and peptidomimetics.

引用

页码：1935 / 1950

页数：16

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