Use of ixekizumab in an HIV-positive patient with psoriatic arthritis

被引：3

作者：

Qian, Feng ^{[1
]}

Yan, Yujuan ^{[1
]}

Huang, Jinlong ^{[1
]}

Xu, Weilu ^{[1
]}

Zhu, Yueping ^{[1
]}

Liu, Jin ^{[1
]}

Wu, Xuehua ^{[1
]}

Chen, Fan ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Infect Dis Hosp, Dept Infect Dis, 10 Guangqian Rd, Suzhou 215013, Peoples R China

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2022年 / 33卷 / 05期

关键词：

HIV-1; psoriatic arthritis; anti-IL-17; Ixekizumab; biologic treatment; INFECTION; COUNTS;

D O I：

10.1177/09564624221076289

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Psoriasis is a chronic immune-mediated disease of the skin. The incidence of psoriasis among people living with HIV (PLHIV) is higher than that in the general population. The mechanism is complex, the manifestations are varied, and the treatment is difficult. Biotherapy has greatly alleviated psoriasis, but clinical trials often exclude PLHIV, and evidence is limited to case reports. Here, we report a man living with psoriatic arthritis who had poor response to traditional treatments. After receiving the anti-interleukin (IL)-17 monoclonal antibody (ixekizumab), the arthritis symptoms were significantly relieved, while CD4(+) T cell count increased and the viral load of HIV-1 remained undetectable in combination with antiretroviral therapy (ART). In conclusion, anti-IL-17 monoclonal antibody is a promising and safe treatment for psoriatic arthritis in HIV-positive patients.

引用

页码：519 / 521

页数：3

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