Monitoring tumor motion by real time 2D/3D registration during radiotherapy

被引：67

作者：

Gendrin, Christelle ^{[1
]}

Furtado, Hugo ^{[1
]}

Weber, Christoph ^{[1
]}

Bloch, Christoph ^{[1
]}

Figl, Michael ^{[1
]}

Pawiro, Supriyanto Ardjo ^{[1
]}

Bergmann, Helmar ^{[1
]}

Stock, Markus ^{[2
]}

Fichtinger, Gabor ^{[1
,3
]}

Georg, Dietmar ^{[2
]}

Birkfellner, Wolfgang ^{[1
]}

机构：

[1] Med Univ Vienna, Ctr Med Phys & Biomed Engn, Vienna, Austria

[2] Med Univ Vienna, Dept Radiotherapy, Vienna, Austria

[3] Queens Univ, Dept Comp Sci, Kingston, ON K7L 3N6, Canada

来源：

RADIOTHERAPY AND ONCOLOGY | 2012年 / 102卷 / 02期

基金：

奥地利科学基金会;

关键词：

2D/3D registration; Radiotherapy; Organ motion; INTRAFRACTION MOTION; RESPIRATION TRACKING; LUNG; VALIDATION; PROSTATE; 4D-CT; IGRT;

D O I：

10.1016/j.radonc.2011.07.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and purpose: In this paper, we investigate the possibility to use X-ray based real time 2D/3D registration for non-invasive tumor motion monitoring during radiotherapy. Materials and methods: The 2D/3D registration scheme is implemented using general purpose computation on graphics hardware (GPGPU) programming techniques and several algorithmic refinements in the registration process. Validation is conducted off-line using a phantom and five clinical patient data sets. The registration is performed on a region of interest (ROI) centered around the planned target volume (PTV). Results: The phantom motion is measured with an rms error of 2.56 mm. For the patient data sets, a sinusoidal movement that clearly correlates to the breathing cycle is shown. Videos show a good match between X-ray and digitally reconstructed radiographs (DRR) displacement. Mean registration time is 0.5 s. Conclusions: We have demonstrated that real-time organ motion monitoring using image based marker-less registration is feasible. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 102 (2012) 274-280

引用

页码：274 / 280

页数：7

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