Design and Stability Improvement of Pectin-Based Red Blood Cell-Mimicking Microcapsules for Oxygen Therapeutics

被引：1

作者：

Phakousonh, Damien ^{[1
]}

Wang, Yale ^{[2
]}

Schlicht, Sabrina ^{[1
]}

Wiskirchen, Sam ^{[1
]}

Bos, Trevor ^{[1
]}

Ren, Lixia ^{[3
]}

Chen, Junhong ^{[2
,4
,5
]}

Hua, Xiaolin ^{[6
]}

Lee, Jung ^{[1
]}

Krishnan, Sasirekha ^{[7
]}

Suresh, K. Shoma ^{[7
]}

Jaisankar, Abinaya ^{[7
]}

Ramalingam, Murugan ^{[7
]}

Zhang, Wujie ^{[1
]}

机构：

[1] Milwaukee Sch Engn, Phys & Chem Dept, BioMol Engn Program, Milwaukee, WI 53202 USA

[2] Univ Wisconsin, Dept Mech Engn, Milwaukee, WI 53211 USA

[3] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China

[4] Univ Chicago, Pritzker Sch Mol Engn, Chicago, IL 60637 USA

[5] Argonne Natl Lab, Phys Sci & Engn Directorate, Lemont, IL 60439 USA

[6] Tongji Univ, Shanghai Matern & Infant Hosp 1, Dept Obstet, Sch Med, Shanghai 201204, Peoples R China

[7] Vellore Inst Technol, Sch Mech Engn, Biomat & Organ Engn Grp, Ctr Biomat Cellular & Mol Theranost, Vellore 632014, Tamil Nadu, India

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2021年 / 17卷 / 09期

关键词：

Microcapsules; Oxygen Therapeutics; Pectin; Oligochitosan; Hydrogel; BOVINE HEMOGLOBIN; GLUTARALDEHYDE; ALGINATE;

D O I：

10.1166/jbn.2021.3154

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A pectin-oligochitosan microcapsule system has recently been developed for novel oxygen therapeutic design. To improve IP: 49.249.253.194 On: Mon, 25 Oct 2021 08:53:20 Copyight Ame ic n S ie tifi Publi he s the stability of the pectin-oligochitosan microcapsules in physiological conditions, both covalent (glutaraldehyde) and non De ivered by Ingenta covalent (Mn2+ and Ca2+) cross-linkers were tested. The chemistry and morphology of the microcapsules were studied using FTIR and SEM, respectively. Results showed that glutaraldehyde is an effective cross-linker, even at low concentrations and short incubation times, and the glutaraldehyde cross-linking does not negatively impact the morphology of the microcapsules. Moreover, it was confirmed that the hemoglobin could be retained within the microcapsules with a minimal release.

引用

页码：1798 / 1805

页数：8

共 26 条

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