Can the Irradiated Brain Be Salvaged by Oligodendrocyte Precursor Transplantation?

被引:6
|
作者
Harrisingh, Marie C. [1 ]
Ffrench-Constant, Charles [1 ]
机构
[1] Univ Edinburgh, MRC Ctr Regenerat Med, Edinburgh EH16 4UU, Midlothian, Scotland
关键词
PROGENITOR CELLS; CNS;
D O I
10.1016/j.stem.2015.01.010
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Radiotherapy is a mainstay of brain cancer treatment, but it causes significant complications. In this issue of Cell Stem Cell, Piao et al. (2015) derive oligodendrocyte precursors from human embryonic stem cells and show that engrafted cells replenish depleted precursor numbers, generate new myelin, and reverse behavioral defects in irradiated rats.
引用
收藏
页码:113 / 114
页数:2
相关论文
共 50 条
  • [31] A morphological and electrophysiological study on the postnatal development of oligodendrocyte precursor cells in the rat brain
    Chen, Peng-Hui
    Cai, Wen-qin
    Wang, Li-yan
    Deng, Qi-yue
    BRAIN RESEARCH, 2008, 1243 : 27 - 37
  • [32] Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain
    Christina Dimovasili
    Ashley E. Fair
    Isabella R. Garza
    Katelyn V. Batterman
    Farzad Mortazavi
    Tara L. Moore
    Douglas L. Rosene
    GeroScience, 2023, 45 : 249 - 264
  • [33] Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord
    Khandker, Luipa
    Jeffries, Marisa A.
    Chang, Yun-Juan
    Mather, Marie L.
    Evangelou, Angelina, V
    Bourne, Jennifer N.
    Tafreshi, Azadeh K.
    Ornelas, Isis M.
    Bozdagi-Gunal, Ozlem
    Macklin, Wendy B.
    Wood, Teresa L.
    CELL REPORTS, 2022, 38 (09):
  • [34] The responses of oligodendrocyte precursor cells, astrocytes and microglia to a cortical stab injury, in the brain
    Hampton, DW
    Rhodes, KE
    Zhao, C
    Franklin, RJM
    Fawcett, JW
    NEUROSCIENCE, 2004, 127 (04) : 813 - 820
  • [35] Can oligodendrocyte precursor cells be a therapeutic target for mitigating cognitive decline in cerebrovascular disease?
    Arai, Ken
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2020, 40 (08): : 1735 - 1736
  • [36] Can infected composite mesh be salvaged?
    Greenberg, J. J.
    HERNIA, 2010, 14 (06) : 589 - 592
  • [37] Quality of blood salvaged and irradiated during cancer surgery
    Hansen, E
    Altmeppen, J
    Marienhagen, J
    Taeger, K
    TRANSFUSION, 1999, 39 (10) : 58S - 58S
  • [38] PROBLEM PEOPLE - MANY CAN BE SALVAGED
    不详
    METALWORKING ECONOMICS, 1971, 27 (07): : 32 - &
  • [39] Can infected composite mesh be salvaged?
    J. J. Greenberg
    Hernia, 2010, 14 : 589 - 592
  • [40] Torsion of the cryptorchid testis - Can it be salvaged?
    Zilberman, Dorit
    Inbar, Yael
    Heyman, Zehava
    Shinhar, Danny
    Bilik, Ron
    Avigad, Itamar
    Jonas, Paul
    Ramon, Jacob
    Mor, Yoram
    JOURNAL OF UROLOGY, 2006, 175 (06): : 2287 - 2289