Clonal Hematopoiesis: A New Layer in the Liquid Biopsy Story in Lung Cancer

被引:39
|
作者
Bauml, Joshua [1 ]
Levy, Benjamin [2 ]
机构
[1] Univ Penn, Abrahamson Canc Ctr, Philadelphia, PA 19104 USA
[2] Sibley Mem Hosp, Johns Hopkins Sidney Kimmel Canc Ctr, Washington, DC USA
关键词
OF-AMERICAN-PATHOLOGISTS;
D O I
10.1158/1078-0432.CCR-18-0969
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cell-free DNA (cfDNA) is a unique biospecimen that contains multiple sources of DNA, including tumor, germline, fetal, and others. Clonal hematopoiesis, a process that leads to expansion of mutations in peripheral blood cells, is an additional source of DNA that adds a layer of complexity when interpreting results. Clin Cancer Res; 24(18); 4352-4. (C) 2018 AACR.
引用
收藏
页码:4352 / 4354
页数:3
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