Deficiency in Androgen Receptor Aggravates Traumatic Brain Injury-Induced Pathophysiology and Motor Deficits in Mice
被引:5
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作者:
Chen, Yu-Hsin
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Taipei Med Univ, Coll Med, Grad Inst Med Sci, Taipei 11031, TaiwanTaipei Med Univ, Coll Med, Grad Inst Med Sci, Taipei 11031, Taiwan
Chen, Yu-Hsin
[1
]
Chen, Yen-Chou
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机构:
Taipei Med Univ, Coll Med, Grad Inst Med Sci, Taipei 11031, TaiwanTaipei Med Univ, Coll Med, Grad Inst Med Sci, Taipei 11031, Taiwan
Chen, Yen-Chou
[1
]
Hwang, Ling-Ling
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Taipei Med Univ, Coll Med, Grad Inst Med Sci, Taipei 11031, TaiwanTaipei Med Univ, Coll Med, Grad Inst Med Sci, Taipei 11031, Taiwan
Hwang, Ling-Ling
[1
]
Yang, Liang-Yo
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机构:
China Med Univ, Coll Med, Sch Med, Dept Physiol, Taichung 40402, Taiwan
China Med Univ Hosp, Dept Med Res, Lab Neural Repair, Taichung 40447, TaiwanTaipei Med Univ, Coll Med, Grad Inst Med Sci, Taipei 11031, Taiwan
Yang, Liang-Yo
[2
,3
]
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机构:
Lu, Dah-Yuu
[4
,5
]
机构:
[1] Taipei Med Univ, Coll Med, Grad Inst Med Sci, Taipei 11031, Taiwan
[2] China Med Univ, Coll Med, Sch Med, Dept Physiol, Taichung 40402, Taiwan
[3] China Med Univ Hosp, Dept Med Res, Lab Neural Repair, Taichung 40447, Taiwan
[4] China Med Univ, Sch Med, Dept Pharmacol, Taichung 404333, Taiwan
Androgens have been shown to have a beneficial effect on brain injury and lower reactive astrocyte expression after TBI. Androgen receptors (ARs) are known to mediate the neuroprotective effects of androgens. However, whether ARs play a crucial role in TBI remains unknown. In this study, we investigated the role of ARs in TBI pathophysiology, using AR knockout (ARKO) mice. We used the controlled cortical impact model to produce primary and mechanical brain injuries and assessed motor function and brain-lesion volume. In addition, the AR knockout effects on necrosis and autophagy were evaluated after TBI. AR knockout significantly increased TBI-induced expression of the necrosis marker alpha-II-spectrin breakdown product 150 and astrogliosis marker glial fibrillary acidic protein. In addition, the TBI-induced astrogliosis increase in ARKO mice lasted for three weeks after a TBI. The autophagy marker Beclin-1 was also enhanced in ARKO mice compared with wild-type mice after TBI. Our results also indicated that ARKO mice showed a more unsatisfactory performance than wild-type mice in a motor function test following TBI. Further, they were observed to have more severe lesions than wild-type mice after injury. These findings strongly suggest that ARs play a role in TBI.
机构:
Univ Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15213 USAUniv Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15213 USA
Olsen, Adam S.
Sozda, Christopher N.
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Univ Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15213 USAUniv Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15213 USA
Sozda, Christopher N.
Cheng, Jeffrey P.
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Univ Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15213 USAUniv Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15213 USA
Cheng, Jeffrey P.
Hoffman, Ann N.
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Univ Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15213 USAUniv Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15213 USA
Hoffman, Ann N.
Kline, Anthony E.
论文数: 0引用数: 0
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机构:
Univ Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Ctr Neurosci, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Ctr Neural Basis Cognit, Pittsburgh, PA 15213 USAUniv Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15213 USA
机构:
Army Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R ChinaArmy Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R China
Chen, Weixiang
Xia, Min
论文数: 0引用数: 0
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机构:
Army Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R ChinaArmy Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R China
Xia, Min
Guo, Chao
论文数: 0引用数: 0
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机构:
Army Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R ChinaArmy Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R China
Guo, Chao
Jia, Zhengcai
论文数: 0引用数: 0
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机构:
Army Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R ChinaArmy Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R China
Jia, Zhengcai
Wang, Jie
论文数: 0引用数: 0
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机构:
Army Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R ChinaArmy Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R China
Wang, Jie
Li, Chengcheng
论文数: 0引用数: 0
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机构:
Army Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R ChinaArmy Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R China
Li, Chengcheng
Li, Mingxi
论文数: 0引用数: 0
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机构:
Army Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R ChinaArmy Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R China
Li, Mingxi
Tang, Xiaoqin
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机构:
Army Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R ChinaArmy Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R China
Tang, Xiaoqin
Hu, Rong
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机构:
Army Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R ChinaArmy Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R China
Hu, Rong
Chen, Yujie
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Army Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R ChinaArmy Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R China
Chen, Yujie
Liu, Xin
论文数: 0引用数: 0
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机构:
Army Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R ChinaArmy Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R China
Liu, Xin
Feng, Hua
论文数: 0引用数: 0
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机构:
Army Med Univ, Collaborat Innovat Ctr Brain Res, Third Mil Med Univ, Southwest Hosp,Dept Neurosurg, 29 Gaotanyan St, Chongqing 400038, Peoples R ChinaArmy Med Univ, Southwest Hosp, Dept Neurosurg, Third Mil Med Univ, 29 Gaotanyan St, Chongqing 400038, Peoples R China
机构:
Tianjin Med Univ, Gen Hosp, Tianjin Inst Neurol, Dept Neurosurg, Tianjin, Peoples R ChinaTianjin Med Univ, Gen Hosp, Tianjin Inst Neurol, Dept Neurosurg, Tianjin, Peoples R China
Zhang, Chao-Nan
Li, Fan-Jian
论文数: 0引用数: 0
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Tianjin Med Univ, Gen Hosp, Tianjin Inst Neurol, Dept Neurosurg, Tianjin, Peoples R ChinaTianjin Med Univ, Gen Hosp, Tianjin Inst Neurol, Dept Neurosurg, Tianjin, Peoples R China
Li, Fan-Jian
Zhao, Zi-Long
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Tianjin Med Univ, Gen Hosp, Tianjin Inst Neurol, Dept Neurosurg, Tianjin, Peoples R ChinaTianjin Med Univ, Gen Hosp, Tianjin Inst Neurol, Dept Neurosurg, Tianjin, Peoples R China
Zhao, Zi-Long
Zhang, Jian-Ning
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机构:
Tianjin Med Univ, Gen Hosp, Tianjin Inst Neurol, Dept Neurosurg, Tianjin, Peoples R ChinaTianjin Med Univ, Gen Hosp, Tianjin Inst Neurol, Dept Neurosurg, Tianjin, Peoples R China
机构:
Tel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel
Namdar, I
Feldman, R.
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机构:
Tel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel
Feldman, R.
Glazer, S.
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机构:
Tel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel
Glazer, S.
Meningher, I
论文数: 0引用数: 0
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机构:
Tel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, Sagol Sch Neurosci, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel
Meningher, I
Shlobin, N. A.
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机构:
Tel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel
Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USATel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel
Shlobin, N. A.
Rubovitch, V
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Tel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel
Rubovitch, V
Bikovski, L.
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Tel Aviv Univ, Sackler Sch Med, Myers Neurobehav Core Facil, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel
Bikovski, L.
Been, E.
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Tel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel
Ono Acad Coll, Fac Hlth Profess, Dept Sports Therapy, IL-5545001 Kiryat Ono, IsraelTel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel
Been, E.
Pick, Chaim G.
论文数: 0引用数: 0
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机构:
Tel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, Sagol Sch Neurosci, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, Ctr Biol Addict Dis, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel