Deficiency in Androgen Receptor Aggravates Traumatic Brain Injury-Induced Pathophysiology and Motor Deficits in Mice

被引:5
|
作者
Chen, Yu-Hsin [1 ]
Chen, Yen-Chou [1 ]
Hwang, Ling-Ling [1 ]
Yang, Liang-Yo [2 ,3 ]
Lu, Dah-Yuu [4 ,5 ]
机构
[1] Taipei Med Univ, Coll Med, Grad Inst Med Sci, Taipei 11031, Taiwan
[2] China Med Univ, Coll Med, Sch Med, Dept Physiol, Taichung 40402, Taiwan
[3] China Med Univ Hosp, Dept Med Res, Lab Neural Repair, Taichung 40447, Taiwan
[4] China Med Univ, Sch Med, Dept Pharmacol, Taichung 404333, Taiwan
[5] Asia Univ, Dept Photon & Commun Engn, Taichung 404333, Taiwan
来源
MOLECULES | 2021年 / 26卷 / 20期
关键词
traumatic brain injury; controlled cortical impact; androgen receptor; ARKO mice; motor activity; ALPHA-II-SPECTRIN; CONTROLLED CORTICAL IMPACT; CEREBROSPINAL-FLUID; BREAKDOWN PRODUCTS; RAT MODEL; SIGNALING PATHWAY; PROTECTIVE ROLE; CELL-DEATH; BECLIN; AUTOPHAGY;
D O I
10.3390/molecules26206250
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Androgens have been shown to have a beneficial effect on brain injury and lower reactive astrocyte expression after TBI. Androgen receptors (ARs) are known to mediate the neuroprotective effects of androgens. However, whether ARs play a crucial role in TBI remains unknown. In this study, we investigated the role of ARs in TBI pathophysiology, using AR knockout (ARKO) mice. We used the controlled cortical impact model to produce primary and mechanical brain injuries and assessed motor function and brain-lesion volume. In addition, the AR knockout effects on necrosis and autophagy were evaluated after TBI. AR knockout significantly increased TBI-induced expression of the necrosis marker alpha-II-spectrin breakdown product 150 and astrogliosis marker glial fibrillary acidic protein. In addition, the TBI-induced astrogliosis increase in ARKO mice lasted for three weeks after a TBI. The autophagy marker Beclin-1 was also enhanced in ARKO mice compared with wild-type mice after TBI. Our results also indicated that ARKO mice showed a more unsatisfactory performance than wild-type mice in a motor function test following TBI. Further, they were observed to have more severe lesions than wild-type mice after injury. These findings strongly suggest that ARs play a role in TBI.
引用
收藏
页数:16
相关论文
共 50 条
  • [21] Traumatic brain injury-induced cerebral microbleeds in the elderly
    Toth, Luca
    Czigler, Andras
    Horvath, Peter
    Kornyei, Balint
    Szarka, Nikolett
    Schwarcz, Attila
    Ungvari, Zoltan
    Buki, Andras
    Toth, Peter
    GEROSCIENCE, 2021, 43 (01) : 125 - 136
  • [22] Traumatic brain injury-induced cerebral microbleeds in the elderly
    Luca Toth
    Andras Czigler
    Peter Horvath
    Balint Kornyei
    Nikolett Szarka
    Attila Schwarcz
    Zoltan Ungvari
    Andras Buki
    Peter Toth
    GeroScience, 2021, 43 : 125 - 136
  • [23] Web Application for Quantification of Traumatic Brain Injury-Induced Cortical Lesions in Adult Mice
    Ciszek, Robert
    Andrade, Pedro
    Tapiala, Jesse
    Pitkanen, Asla
    Ndode-Ekane, Xavier Ekolle
    NEUROINFORMATICS, 2020, 18 (02) : 307 - 317
  • [24] Web Application for Quantification of Traumatic Brain Injury-Induced Cortical Lesions in Adult Mice
    Robert Ciszek
    Pedro Andrade
    Jesse Tapiala
    Asla Pitkänen
    Xavier Ekolle Ndode-Ekane
    Neuroinformatics, 2020, 18 : 307 - 317
  • [25] Human umbilical cord blood cells rescued traumatic brain injury-induced cardiac and neurological deficits
    Hu, Haotian
    Zhao, Qiang
    Liu, Xiaoxuan
    Yan, Tao
    ANNALS OF TRANSLATIONAL MEDICINE, 2020, 8 (06)
  • [26] Administration of haloperidol and risperidone after neurobehavioral testing hinders the recovery of traumatic brain injury-induced deficits
    Hoffman, Ann N.
    Cheng, Jeffrey P.
    Zafonte, Ross D.
    Kline, Anthony E.
    LIFE SCIENCES, 2008, 83 (17-18) : 602 - 607
  • [27] Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation
    Cao, Rong
    Li, Lin
    Zhang, Wen
    Lu, Jun
    Wang, Yu
    Chen, Qian
    Zhang, Wentong
    Chen, Mingming
    Sheng, Liang
    Cai, Keshu
    Xu, Guangxu
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 580 : 20 - 27
  • [28] CHRONIC AND PROGRESSIVE MOTOR DEFICITS AND CEREBRAL ATROPHY FOLLOWING A SINGLE TRAUMATIC BRAIN INJURY IN MICE
    Lawless, Siobhan
    Siefert, Alan
    Crary, John F.
    Havlicek, David F.
    Kelley, Craig
    Nikulina, Elena
    Bergold, Peter J.
    JOURNAL OF NEUROTRAUMA, 2021, 38 (14) : A105 - A105
  • [29] Analysis of fine motor deficits following traumatic brain injury
    Buhmann, S
    Marquardt, C
    Hermsdörfer, J
    JOURNAL OF NEUROLOGY, 2004, 251 : 114 - 115
  • [30] Ghrelin decreases motor deficits after traumatic brain injury
    Lopez, Nicole E.
    Lindsay, Gaston
    Karina, Lopez R.
    Mary, Hageny A.
    Putnam, James
    Eliceiri, Brian
    Coimbra, Raul
    Bansal, Vishal
    JOURNAL OF SURGICAL RESEARCH, 2014, 187 (01) : 230 - 236