An efficient and recyclable L-proline triflate ionic liquid catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones via the multi-component Biginelli reaction

被引：9
|
作者：
Khan Manh Hua [1 ]
Phuong Hoang Tran [1 ]
Thach Ngoc Le [1 ]
机构：
[1] Vietnam Natl Univ, Univ Sci, Fac Chem, Dept Organ Chem, Ho Chi Minh City 700000, Vietnam
来源：
ARKIVOC | 2019年
关键词：
Biginelli reaction; ultrasonic irradiation; microwave irradiation; L-proline triflate; solvent-free conditions; ASSISTED SYNTHESIS; NANOPARTICLES; ULTRASOUND; GREEN;
D O I：
10.24820/ark.5550190.p011.096
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, efficient, and environmentally-friendly process has been developed for the synthesis of L-proline triflate ionic liquid (L-ProTfO) from L-proline and triflic acid using ultrasound irradiation. The combination of Lproline triflate ionic liquid technology with microwave energy represents an attractive and rapid alternative to the conventional acid-base-catalyzed thermal process. The current method has several advantages, including high yield, short reaction time, and work-up simplicity. In addition, the L-proline triflate ionic liquid could be recycled and reused four times without a noticeable decrease in catalytic activity. [GRAPHICS] .
引用
收藏
页码：406 / 415
页数：10
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