Silica Gel-Supported Polyphosphoric Acid (PPA-SiO2) Catalyzed One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and -thiones: An Efficient Method for the Biginelli Reaction

被引：88
|
作者：
Zeinali-Dastmalbaf, Mohsen [1 ]
Davoodnia, Abolghasem [1 ]
Heravi, Majid M. [2 ]
Tavakoli-Hoseini, Niloofar [1 ]
Khojastehnezhad, Amir [1 ]
Zamani, Hassan Ali [3 ]
机构：
[1] Islamic Azad Univ, Mashhad Branch, Dept Chem, Fac Sci, Mashhad, Iran
[2] Alzahra Univ, Sch Sci, Dept Chem, Tehran, Iran
[3] Islamic Azad Univ, Quchan Branch, Dept Appl Chem, Quchan, Iran
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2011年 / 32卷 / 02期
关键词：
Biginelli reaction; Heterogeneous catalysis; PPA-SiO2; Multi-component reactions; SOLVENT-FREE CONDITIONS; HIGH-YIELDING PROTOCOL; REUSABLE CATALYST; 1,2,4,5-TETRASUBSTITUTED IMIDAZOLES; MICROWAVE IRRADIATION; IONIC LIQUID; DERIVATIVES; DIHYDROPYRIMIDINONES; TRIFLATE; ALDEHYDES;
D O I：
10.5012/bkcs.2011.32.2.656
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A green and efficient method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones through one-pot three-component reaction of ethyl acetoacetate, an aryl aldehyde, and urea or thiourea in acetonitrile using silica gel-supported polyphosphoric acid (PPA-SiO2) as catalyst is described. Compared to the classical Biginelli reaction conditions, the present methodology offers several advantages such as high yields, relatively short reaction times, mild reaction condition and a recyclable catalyst with a very easy work up.
引用
收藏
页码：656 / 658
页数：3
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