Silica Gel-Supported Polyphosphoric Acid (PPA-SiO2) Catalyzed One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and -thiones: An Efficient Method for the Biginelli Reaction

被引：88

作者：

Zeinali-Dastmalbaf, Mohsen ^{[1
]}

Davoodnia, Abolghasem ^{[1
]}

Heravi, Majid M. ^{[2
]}

Tavakoli-Hoseini, Niloofar ^{[1
]}

Khojastehnezhad, Amir ^{[1
]}

Zamani, Hassan Ali ^{[3
]}

机构：

[1] Islamic Azad Univ, Mashhad Branch, Dept Chem, Fac Sci, Mashhad, Iran

[2] Alzahra Univ, Sch Sci, Dept Chem, Tehran, Iran

[3] Islamic Azad Univ, Quchan Branch, Dept Appl Chem, Quchan, Iran

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2011年 / 32卷 / 02期

关键词：

Biginelli reaction; Heterogeneous catalysis; PPA-SiO2; Multi-component reactions; SOLVENT-FREE CONDITIONS; HIGH-YIELDING PROTOCOL; REUSABLE CATALYST; 1,2,4,5-TETRASUBSTITUTED IMIDAZOLES; MICROWAVE IRRADIATION; IONIC LIQUID; DERIVATIVES; DIHYDROPYRIMIDINONES; TRIFLATE; ALDEHYDES;

D O I：

10.5012/bkcs.2011.32.2.656

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A green and efficient method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones through one-pot three-component reaction of ethyl acetoacetate, an aryl aldehyde, and urea or thiourea in acetonitrile using silica gel-supported polyphosphoric acid (PPA-SiO2) as catalyst is described. Compared to the classical Biginelli reaction conditions, the present methodology offers several advantages such as high yields, relatively short reaction times, mild reaction condition and a recyclable catalyst with a very easy work up.

引用

页码：656 / 658

页数：3

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