Simple synthesis of 1,1-bis(trifluoromethyl)cyclopropanes

被引：11

作者：

Petrov, Viacheslav A. ^{[1
]}

Marshall, Will ^{[2
]}

机构：

[1] DuPont Cent Res & Dev, Expt Stn, Wilmington, DE 19880 USA

[2] DuPont Corp Ctr Analyt Sci, Expt Stn, Wilmington, DE 19880 USA

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2012年 / 133卷

关键词：

2,2-Bis(trifluoromethyl)thietanes; Reaction with phosphines; Desulfurization; Formation of 1,1-bis(trifluoromethyl)cyclopropanes; ORGANIC SULFUR CHEMISTRY; DESULFURIZATION; ACIDS;

D O I：

10.1016/j.jfluchem.2011.06.022

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new, simple synthesis of 1,1-bis(trifluoromethyl)cyclopropanes has been discovered. It is based on the reaction of readily available 2,2-bis(trifluoromethyl)thietanes with tertiary phosphines in a polar solvent, which leads to an unusual desulfurization process, resulting in the formation of 1,1-bis(trifluoromethyl)-2-alkoxy cyclopropanes. The process of the corresponding thietanes appears to be sensitive to the steric volume of the atom connected to carbon in a-position to sulfur. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：61 / 66

页数：6

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