Simple synthesis of 1,1-bis(trifluoromethyl)cyclopropanes

被引：11
|
作者：
Petrov, Viacheslav A. [1 ]
Marshall, Will [2 ]
机构：
[1] DuPont Cent Res & Dev, Expt Stn, Wilmington, DE 19880 USA
[2] DuPont Corp Ctr Analyt Sci, Expt Stn, Wilmington, DE 19880 USA
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2012年 / 133卷
关键词：
2,2-Bis(trifluoromethyl)thietanes; Reaction with phosphines; Desulfurization; Formation of 1,1-bis(trifluoromethyl)cyclopropanes; ORGANIC SULFUR CHEMISTRY; DESULFURIZATION; ACIDS;
D O I：
10.1016/j.jfluchem.2011.06.022
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new, simple synthesis of 1,1-bis(trifluoromethyl)cyclopropanes has been discovered. It is based on the reaction of readily available 2,2-bis(trifluoromethyl)thietanes with tertiary phosphines in a polar solvent, which leads to an unusual desulfurization process, resulting in the formation of 1,1-bis(trifluoromethyl)-2-alkoxy cyclopropanes. The process of the corresponding thietanes appears to be sensitive to the steric volume of the atom connected to carbon in a-position to sulfur. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：61 / 66
页数：6
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