New fACEs to the renin-angiotensin system

被引:52
|
作者
Fleming, I [1 ]
Kohlstedt, K [1 ]
Busse, R [1 ]
机构
[1] Univ Frankfurt, Inst Kardiovaskulare Physiol, Vasc Signaling Grp, D-6000 Frankfurt, Germany
关键词
D O I
10.1152/physiol.00003.2005
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Inhibition of the angiotensin-converting enzyme (ACE) protects against the progression of several cardiovascular diseases. Recent evidence suggests that some of the beneficial effects of ACE inhibitors can be attributed to the activation of a distinct ACE signaling cascade rather than to the changes in angiotensin II and bradykinin levels. Moreover, at least one other ACE homolog (ACE2) plays a significant role in the regulation of heart and kidney function.
引用
收藏
页码:91 / 95
页数:5
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