New fACEs to the renin-angiotensin system

被引：52
|
作者：
Fleming, I [1 ]
Kohlstedt, K [1 ]
Busse, R [1 ]
机构：
[1] Univ Frankfurt, Inst Kardiovaskulare Physiol, Vasc Signaling Grp, D-6000 Frankfurt, Germany
来源：
PHYSIOLOGY | 2005年 / 20卷
关键词：
D O I：
10.1152/physiol.00003.2005
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Inhibition of the angiotensin-converting enzyme (ACE) protects against the progression of several cardiovascular diseases. Recent evidence suggests that some of the beneficial effects of ACE inhibitors can be attributed to the activation of a distinct ACE signaling cascade rather than to the changes in angiotensin II and bradykinin levels. Moreover, at least one other ACE homolog (ACE2) plays a significant role in the regulation of heart and kidney function.
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页码：91 / 95
页数：5
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