AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3

被引:305
|
作者
Wunderlich, M. [1 ]
Chou, F-S [1 ]
Link, K. A. [1 ]
Mizukawa, B. [2 ]
Perry, R. L. [3 ]
Carroll, M. [4 ]
Mulloy, J. C. [1 ]
机构
[1] Cincinnati Childrens Hosp, Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH USA
[2] Cincinnati Childrens Hosp, Med Ctr, Div Hematol & Oncol, Cincinnati, OH USA
[3] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA
[4] Univ Penn, Div Hematol & Oncol, Philadelphia, PA 19104 USA
关键词
HEMATOPOIETIC STEM-CELLS; ACUTE MYELOID-LEUKEMIA; MODEL; ENGRAFTMENT;
D O I
10.1038/leu.2010.158
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1785 / 1788
页数:4
相关论文
共 50 条
  • [31] Differential regulation of human eosinophil IL-3, IL-5, and GM-CSF receptor α-chain expression by cytokines:: IL-3, IL-5, and GM-CSF down-regulate IL-5 receptor α expression with loss of IL-5 responsiveness, but up-regulate IL-3 receptor a expression
    Gregory, B
    Kirchem, A
    Phipps, S
    Gevaert, P
    Pridgeon, C
    Rankin, SM
    Robinson, DS
    JOURNAL OF IMMUNOLOGY, 2003, 170 (11): : 5359 - 5366
  • [32] MODULATION OF NORMAL HUMAN MYELOID PROGENITOR GROWTH BY IL-3, G-CSF OR GM-CSF ASSOCIATED TO IL-6
    DELFORGE, A
    LAGNEAUX, L
    DEBRUYN, C
    BRON, D
    STRYCKMANS, P
    EXPERIMENTAL HEMATOLOGY, 1991, 19 (06) : 510 - 510
  • [33] IL-3, IL-5, and GM-CSF signaling: Crystal structure of the human beta-common receptor
    Murphy, James M.
    Young, Ian G.
    INTERLEUKINS, 2006, 74 : 1 - 30
  • [34] Interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) can induce differentiation of chronic B cell leukemia expressing the alpha subunit of IL-3 and GM-CSF receptor
    Shiiba, M
    Takaki, S
    Takatsu, K
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1996, 111 : 12 - 15
  • [35] RECOMBINANT GM-CSF/IL-3 FUSION PROTEIN - ITS EFFECT ON INVITRO HUMAN MEGAKARYOCYTOPOIESIS
    BRUNO, E
    BRIDDELL, RA
    COOPER, RJ
    BRANDT, JE
    HOFFMAN, R
    EXPERIMENTAL HEMATOLOGY, 1992, 20 (04) : 494 - 499
  • [36] FUNCTIONAL DIFFERENCES BETWEEN ALPHA-SUBUNITS OF THE HUMAN IL-3 AND GM-CSF RECEPTORS
    KITAMURA, T
    SAKAMAKI, K
    MIYAJIMA, A
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, : 77 - 77
  • [37] IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells
    Shibasaki, Tetsunori
    Katayama, Naoyuki
    Ohishi, Kohshi
    Fujieda, Atsushi
    Monma, Fumihiko
    Nishii, Kazuhiro
    Masuya, Masahiro
    Shiku, Hiroshi
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2007, 30 (03) : 549 - 555
  • [38] THE HUMAN GENES FOR GM-CSF AND IL-3 ARE CLOSELY LINKED IN TANDEM ON CHROMOSOME-5
    YANG, YC
    KOVACIC, S
    KRIZ, R
    WOLF, S
    CLARK, SC
    WELLEMS, TE
    NIENHUIS, A
    EPSTEIN, N
    BLOOD, 1988, 71 (04) : 958 - 961
  • [39] Downregulation of tyrosine phosphorylation and intracellular signalling pathways in cells expressing a constitutively activated mutant form of the common β subunit of the GM-CSF, IL-3 and IL-5 receptors.
    Ryder, JW
    Wu, SC
    Hamilton, E
    Hunter, S
    Anderson, SM
    BLOOD, 1998, 92 (10) : 65A - 65A
  • [40] Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung
    Willinger, Tim
    Rongvaux, Anthony
    Takizawa, Hitoshi
    Yancopoulos, George
    Valenzuela, David
    Murphy, Andrew
    Auerbach, Wojtek
    Eynon, Elizabeth
    Stevens, Sean
    Manz, Markus
    Flavell, Richard
    JOURNAL OF IMMUNOLOGY, 2011, 186