Discovery of a dual CCR2/CCR5 antagonist with a superior cardiovascular profile for the treatment of autoimmune diseases

被引：0
|
作者：
Hughes, Robert O. [1 ]
Rogier, D. Joseph [1 ]
Devraj, Rajesh [1 ]
Xue, Chu-Biao [2 ]
Cao, Ganfeng [2 ]
Turner, Steven R. [1 ]
Morton, Philip A. [1 ]
Keys, Kelly [1 ]
Covington, Maryanne [2 ]
Bond, Brian R. [1 ]
Yu, Ying [1 ]
Meade, Holly [1 ]
Hood, William F. [1 ]
Roeberds, Steve [1 ]
Newton, Robert [2 ]
Metcalf, Brian [2 ]
机构：
[1] Pfizer Res & Dev, Cambridge, MA 02451 USA
[2] Incyte Corp, Willmington, DE 19880 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 242卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
26-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [41] Discovery of a novel CCR2 antagonist as development candidate via divergent SARs of CCR2 and hERG
    Zhang, Xuqing
    Hou, Cuifen
    Hufnagel, Heather
    Markotan, Thomas
    Lanter, James
    Cai, Chaozhong
    Singer, Monica
    Opas, Evan
    McKenney, Sandra
    Crysler, Carl
    Johnson, Dana
    Sui, Zhihua
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [42] Pharmacokinetics, Safety, and CCR2/CCR5 Antagonist Activityof Cenicriviroc in Participants With Mild or Moderate Hepatic Impairment
    Lefebvre, E.
    Gottwald, M.
    Lasseter, K.
    Chang, W.
    Willett, M.
    Smith, P. F.
    Somasunderam, A.
    Utay, N. S.
    CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2016, 9 (03): : 139 - 148
  • [43] Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction
    González, P
    Alvarez, R
    Batalla, A
    Reguero, JR
    Alvarez, V
    Astudillo, A
    Cubero, GI
    Cortina, A
    Coto, E
    GENES AND IMMUNITY, 2001, 2 (04) : 191 - 195
  • [44] Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes
    Connolly, Kelli A.
    Belt, Brian A.
    Figueroa, Nathania M.
    Murthy, Aditi
    Patel, Ankit
    Kim, Minsoo
    Lord, Edith M.
    Linehan, David C.
    Gerber, Scott A.
    ONCOTARGET, 2016, 7 (52) : 86522 - 86535
  • [45] CCR2 and CCR5 genes polymorphisms in benign prostatic hyperplasia and prostate
    Bao Zambra, Francis Maria
    Biolchi, Vanderlei
    Brum, Ilma Simoni
    Bogo Chies, Jose Artur
    HUMAN IMMUNOLOGY, 2013, 74 (08) : 1003 - 1008
  • [46] CCR2 and CCR5 promote diclofenac-induced hepatotoxicity in mice
    Zhanke He
    Guoquan Wei
    Na Li
    Mengwei Niu
    Shenhai Gong
    Guangyan Wu
    Teng Wang
    Yong Jiang
    Peng Chen
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2019, 392 : 287 - 297
  • [47] Allelic distribution of CCR5 and CCR2 genes in an Italian population sample
    Romano-Spica, V
    Ianni, A
    Arzani, D
    Cattarini, L
    Majore, S
    Dean, M
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2000, 16 (02) : 99 - 101
  • [48] Distribution of CCR2 and CCR5 alleles in children with respiratory disorders.
    Romano-Spica, V
    Ianni, A
    Arzani, D
    Majore, S
    AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (04) : 238 - 238
  • [49] CCR2 and CCR5 gene polymorphisms in children with recurrent respiratory infections
    Ianni, A
    Majore, S
    Arzani, D
    Carboni, I
    Corbo, GM
    Romano-Spica, V
    RESPIRATORY MEDICINE, 2001, 95 (05) : 430 - 432
  • [50] Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis
    Zhao, XY
    Gharizadeh, B
    Hjelmström, P
    Pirskanen, R
    Nyrén, P
    Lefvert, AK
    Ghaderi, M
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2003, 12 (05) : 749 - 753
12345