Discovery of a dual CCR2/CCR5 antagonist with a superior cardiovascular profile for the treatment of autoimmune diseases

被引:0
|
作者
Hughes, Robert O. [1 ]
Rogier, D. Joseph [1 ]
Devraj, Rajesh [1 ]
Xue, Chu-Biao [2 ]
Cao, Ganfeng [2 ]
Turner, Steven R. [1 ]
Morton, Philip A. [1 ]
Keys, Kelly [1 ]
Covington, Maryanne [2 ]
Bond, Brian R. [1 ]
Yu, Ying [1 ]
Meade, Holly [1 ]
Hood, William F. [1 ]
Roeberds, Steve [1 ]
Newton, Robert [2 ]
Metcalf, Brian [2 ]
机构
[1] Pfizer Res & Dev, Cambridge, MA 02451 USA
[2] Incyte Corp, Willmington, DE 19880 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
26-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [31] CCR2 and CCR5 expression on monocytes during in vivo culture
    Dagkalis, N
    Xu, H
    Mack, M
    Liversidge, J
    Crane, IJ
    IMMUNOLOGY, 2005, 116 : 75 - 75
  • [32] Dual CCR2/CCR5 Antagonist Cenicriviroc Leads to Potent and Significant Reduction in Proinflammatory CCR2+Monocyte Infiltration in Experimental Acute Liver Injury
    Krenkel, Oliver
    Puengel, Tobias
    Mossanen, Jana C.
    Ergen, Can
    Heymann, Felix
    Lefebvre, Eric
    Trautwein, Christian
    Tacke, Frank
    HEPATOLOGY, 2015, 62 : 1065A - 1065A
  • [33] Rationale of using the dual chemokine receptor CCR2/CCR5 inhibitor cenicriviroc for the treatment of COVID-19
    Files, Daniel Clark
    Tacke, Frank
    O'Sullivan, Alexandra
    Dorr, Patrick
    Ferguson, William G.
    Powderly, William G.
    PLOS PATHOGENS, 2022, 18 (06)
  • [34] Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice
    Mack, M
    Cihak, J
    Simonis, C
    Luckow, B
    Proudfoot, AEI
    Plachy, J
    Brühl, H
    Frink, M
    Anders, HJ
    Vielhauer, V
    Pfirstinger, J
    Stangassinger, M
    Schlöndorff, D
    JOURNAL OF IMMUNOLOGY, 2001, 166 (07): : 4697 - 4704
  • [35] Anti-fibrotic and anti-inflammatory activity of the dual CCR5 and CCR2 antagonist cenicriviroc in a mouse model of NASH
    Lefebvre, E.
    Hashiguchi, T.
    Jenkins, H.
    Nabhan, A.
    Yoneyama, H.
    Friedman, S. L.
    Wolfgang, G. H. I.
    ANTIVIRAL THERAPY, 2013, 18 : A14 - A15
  • [36] WXSH0213, a dual CCR2 and CCR5 antagonist, ameliorates nonalcoholic activity score and liver fibrosis in MCD mice
    Wang, Jianhua
    Luo, Yunfu
    Ba, Yuyong
    Guo, Fengxun
    Xu, Deming
    Li, Jian
    Chen, Shuhui
    Chen, Xiaoxin
    Liu, Xing
    Li, Haijun
    Liu, Zhuowei
    Long, Chaofeng
    HEPATOLOGY, 2017, 66 : 151A - 151A
  • [37] Anti-fibrotic and anti-inflammatory activity of the dual CCR2 and CCR5 antagonist cenicriviroc in a mouse model of NASH
    Lefebvre, Eric
    Hashiguchi, Taishi
    Jenkins, Helen
    Nabhan, Antoun
    Yoneyama, Hiroyuki
    Friedman, Scott L.
    Wolfgang, Grushenka H.
    HEPATOLOGY, 2013, 58 : 221A - 222A
  • [38] Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy
    Bowler, S.
    Siriwardhana, C.
    Mitchell, B. L.
    D'Antoni, M. L.
    Ogata-Arakaki, D.
    Souza, S.
    Yee, R.
    Gangcuangco, L. M. A.
    Chow, D. C.
    Ndhlovu, L. C.
    Shikuma, C.
    HIV RESEARCH & CLINICAL PRACTICE, 2019, 20 (4-5) : 123 - 129
  • [39] Dual Chemokine Receptor CCR2/CCR5 Antagonist Cenicriviroc Ameliorates Lipotoxicity-Induced Insulin Resistance and NASH in Mice
    Ota, Tsuguhito
    Chen, Guanliang
    Nagashimada, Mayumi
    DIABETES, 2019, 68
  • [40] THE DUAL CCR2/CCR5 ANTAGONIST CENICRIVIROC AMELIORATES STEATOHEPATITIS AND FIBROSIS IN VIVO BY INHIBITING THE INFILTRATION OF INFLAMMATORY MONOCYTES INTO INJURED LIVER
    Puengel, T.
    Krenkel, O.
    Mossanen, J.
    Longerich, T.
    Lefebvre, E.
    Trautwein, C.
    Tacke, F.
    JOURNAL OF HEPATOLOGY, 2016, 64 : S160 - S160