Live Demonstration: Sample-to-Answer Nucleic Acid Testing Device for Point-of-Care Applications

被引：0
|
作者：
Choi, Gihoon [1 ]
Guan, Weihua [1 ,2 ]
机构：
[1] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA
[2] Penn State Univ, Dept Biomed Engn, University Pk, PA 16802 USA
来源：
2019 IEEE SENSORS | 2019年
关键词：
Nucleic acid tests; point-of-care; malaria; non-centrifugal; lab-on-a-disc;
D O I：
10.1109/sensors43011.2019.8956936
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
We demonstrate a sample-to-answer nucleic acid testing device. The streamlined nucleic acid sample processing, including DNA extraction, amplification, and real-time detection, are achieved on a single microfluidic reagent disc by actuating the DNA-carrying magnetic beads against stationary reagent droplets. The battery-powered handheld instrument is unprecedentedly integrated with mechanical, thermal and optical subsystems with data connectivity. LCD touchscreen and smartphone connectivity offer a user-friendly interface for easy operation. This versatile platform can be widely disseminated to a variety of other situations that demand portability, connectivity, and ease-of-use.
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