Live Demonstration: Sample-to-Answer Nucleic Acid Testing Device for Point-of-Care Applications

被引：0
|
作者：
Choi, Gihoon [1 ]
Guan, Weihua [1 ,2 ]
机构：
[1] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA
[2] Penn State Univ, Dept Biomed Engn, University Pk, PA 16802 USA
来源：
2019 IEEE SENSORS | 2019年
关键词：
Nucleic acid tests; point-of-care; malaria; non-centrifugal; lab-on-a-disc;
D O I：
10.1109/sensors43011.2019.8956936
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
We demonstrate a sample-to-answer nucleic acid testing device. The streamlined nucleic acid sample processing, including DNA extraction, amplification, and real-time detection, are achieved on a single microfluidic reagent disc by actuating the DNA-carrying magnetic beads against stationary reagent droplets. The battery-powered handheld instrument is unprecedentedly integrated with mechanical, thermal and optical subsystems with data connectivity. LCD touchscreen and smartphone connectivity offer a user-friendly interface for easy operation. This versatile platform can be widely disseminated to a variety of other situations that demand portability, connectivity, and ease-of-use.
引用
收藏
页数：1
相关论文
共 50 条
  • [21] Integrated Microcapillary for Sample-to-Answer Nucleic Acid Pretreatment, Amplification, and Detection
    Zhang, Lu
    Zhang, Yi
    Wang, Chunyan
    Feng, Qiang
    Fan, Fei
    Zhang, Guojun
    Kang, Xixiong
    Qin, Xuzhen
    Sun, Jiashu
    Li, Yinghui
    Jiang, Xingyu
    ANALYTICAL CHEMISTRY, 2014, 86 (20) : 10461 - 10466
  • [22] A sample-to-answer, real-time convective polymerase chain reaction system for point-of-care diagnostics
    Shu, Bowen
    Zhang, Chunsun
    Xing, Da
    BIOSENSORS & BIOELECTRONICS, 2017, 97 : 360 - 368
  • [23] Nucleic Acid Point-of-Care Testing to Improve Diagnostic Preparedness
    Jani, Ilesh, V
    Peter, Trevor F.
    CLINICAL INFECTIOUS DISEASES, 2022, 75 (04) : 723 - 728
  • [24] Miniaturized technology for protein and nucleic acid point-of-care testing
    Olasagasti, Felix
    Carlos Ruiz de Gordoa, Juan
    TRANSLATIONAL RESEARCH, 2012, 160 (05) : 332 - 345
  • [25] A Novel Sample-to-Answer Visual Nucleic Acid Detection System for Adenovirus Detection
    Sun, Kui
    Yang, Xiaodong
    Wang, Yanan
    Guan, Qun
    Fu, Wenliang
    Zhang, Chao
    Liu, Qin
    An, Wenzheng
    Zhao, Yongqi
    Xing, Weiwei
    Xu, Donggang
    MICROBIOLOGY SPECTRUM, 2023, 11 (03):
  • [26] Fast nucleic acid amplification for integration in point-of-care applications
    Brunklaus, Sabine
    Hansen-Hagge, Thomas E.
    Erwes, Julia
    Hoeth, Julian
    Jung, Mathieu
    Latta, Daniel
    Strobach, Xenia
    Winkler, Christian
    Ritzi-Lehnert, Marion
    Drese, Klaus S.
    ELECTROPHORESIS, 2012, 33 (21) : 3222 - 3228
  • [27] AUTOMATED SAMPLE-TO-ANSWER NUCLEIC ACID TESTING WITH FREQUENCY CONTROLLED REAGENT RELEASE FROM CARTRIDGE INTEGRATED STICKPACKS
    Stumpf, F.
    Schwemmer, F.
    Hutzenlaub, T.
    Baumann, D.
    Strohmeier, O.
    von Stetten, F.
    Zengerle, R.
    Mark, D.
    2015 TRANSDUCERS - 2015 18TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS (TRANSDUCERS), 2015, : 743 - 746
  • [28] A sample-to-answer, wearable cloth-based electrochemical sensor (WCECS) for point-of-care detection of glucose in sweat
    Zheng, Lin
    Liu, Yuan
    Zhang, Chunsun
    SENSORS AND ACTUATORS B-CHEMICAL, 2021, 343 (343):
  • [29] Comparison of paper-based nucleic acid extraction materials for point-of-care testing applications
    Tang, Ruihua
    Li, Min
    Yan, Xueyan
    Xie, Mingyue
    Liu, Li Na
    Li, Zedong
    Xu, Feng
    CELLULOSE, 2022, 29 (04) : 2479 - 2495
  • [30] A whole blood sample-to-answer polymer lab-on-a-chip with superhydrophilic surface toward point-of-care technology
    Lee, Kang Kug
    Kim, Myoung-Ok
    Cho, Seokheun
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 162 : 28 - 33
12345