Triptans, serotonin 5-HT1B/1D receptor agonists, represent a milestone in migraine therapeutics: they are effective acute attack therapies with a clear pharmacology and no substantial nonheadache indications.(1) Their mechanism of action has never been entirely defined despite widespread use and the potential utility for medicine development in understanding the effect.
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA
Johnston, Mollie M.
Rapoport, Alan M.
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机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA
New England Ctr Headache, Stamford, CT USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA