Epac Activation Protects Heart From Interleukin-6-Induced Cardiac Dysfunction by Inhibiting Stat/iNOS Signaling

被引：0
|
作者：
Okumura, Satoshi [1 ]
Jin, Meihua [1 ]
Kawamata, Fumika [1 ]
Jin, Hui-Ling [1 ]
Cai, Wenqian [1 ]
Bai, Yunzhe [1 ]
Suita, Kenji [1 ]
Hidaka, Yuko [1 ]
Tsunematsu, Takashi [1 ]
Ishikawa, Yoshihiro [1 ]
机构：
[1] Yokohama City Univ, Cardiovasc Rsch Inst, Yokohama, Kanagawa 232, Japan
来源：
CIRCULATION | 2011年 / 124卷 / 21期
关键词：
Heart failure; Signal transduction; Transgenic models; Beta-adrenergic receptor agonists;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A9907
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation
    Chen, Wei
    Yuan, Hui
    Cao, Wenmin
    Wang, Tianwei
    Chen, Wei
    Yu, Hang
    Fu, Yao
    Jiang, Bo
    Zhou, Hong
    Guo, Hongqian
    Zhao, Xiaozhi
    THERANOSTICS, 2019, 9 (14): : 3980 - 3991
  • [22] Anticancer Activity of Tubulosine through Suppression of Interleukin-6-Induced Janus Kinase 2/Signal Transducer and Activation of Transcription 3 Signaling
    Kim, Byung-Hak
    Yi, Eunhee
    Li, Yu Chen
    Park, In-Chul
    Park, Jung Youl
    Ye, Sang-Kyu
    JOURNAL OF BREAST CANCER, 2019, 22 (03) : 362 - 374
  • [23] α-thrombin inhibits interleukin-6-induced Stat3 signaling and gp130 gene expression in primary cultures of human lung fibroblasts
    Bhat, GJ
    Raghu, G
    Gunaje, JJ
    Idell, S
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 256 (03) : 626 - 630
  • [24] Qingda granule prevents obesity-induced hypertension and cardiac dysfunction by inhibiting adverse Akt signaling activation
    Gao, Qian
    Ma, En
    Chen, Jinxiao
    Zhao, Qiqin
    He, Jia
    Peng, Jun
    Zhu, Weidong
    Ren, Dan-ni
    Wo, Da
    HELIYON, 2022, 8 (12)
  • [25] Transgenic mTOR Expression Protects the Heart from Pressure Overload-Induced Cardiac Dysfunction
    Kusakari, Yolchiro
    Xiao, Chun-Yang
    Kinsella, Stuart D.
    Rosenzweig, Anthony
    Matsui, Takashi
    CIRCULATION, 2008, 118 (18) : S393 - S393
  • [26] Interleukin-18 gene deletion protects against sepsis-induced cardiac dysfunction by inhibiting PP2A activity
    Okuhara, Yoshitaka
    Yokoe, Shunichi
    Iwasaku, Toshihiro
    Eguchi, Akiyo
    Nishimura, Koichi
    Li, Wen
    Oboshi, Makiko
    Naito, Yoshiro
    Mano, Toshiaki
    Asahi, Michio
    Okamura, Haruki
    Masuyama, Tohru
    Hirotani, Shinichi
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2017, 243 : 396 - 403
  • [27] Tetramethylpyrazine Protects Against Chronic Hypobaric Hypoxia-Induced Cardiac Dysfunction by Inhibiting CaMKII Activation in a Mouse Model Study
    Zhang, Pengfei
    Deng, Huifang
    Lan, Xiong
    Shen, Pan
    Bai, Zhijie
    Huangfu, Chaoji
    Wang, Ningning
    Xiao, Chengrong
    Gao, Yehui
    Sun, Yue
    Li, Jiamiao
    Guo, Jie
    Zhou, Wei
    Gao, Yue
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (01)
  • [28] Src-FAK-STAT3 signaling in Interleukin-6-induced lymphatic endothelial cell vascular endothelial growth factor-C expression and lymphangiogenesis
    Huang, Y. H.
    EUROPEAN JOURNAL OF CANCER, 2015, 51 : S7 - S7
  • [29] Microenvironmental Interleukin-6 induced activation of STAT3 signaling in medulloblastoma: Implications for molecular pathology and therapy
    Yan, Shuang
    Chatterjee, Sampurna
    Vardam, Trupti
    Kitahara, Shuji
    Hato, Tai
    Roberge, Sylvie
    Askoxylakis, Vasileios
    Duquette, Mark
    Fukumura, Dai
    Xu, Lei
    Jain, Rakesh
    CANCER RESEARCH, 2016, 76
  • [30] The interplay between glioblastoma and microglia cells leads to endothelial cell monolayer dysfunction via the interleukin-6-induced JAK2/STAT3 pathway
    Couto, Marina
    Coelho-Santos, Vanessa
    Santos, Liliana
    Fontes-Ribeiro, Carlos
    Silva, Ana Paula
    Gomes, Celia M. F.
    JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (11) : 19750 - 19760
12345