Synthesis and Antiviral Activity of Glycyrrhizic-Acid Conjugates with Aromatic Amino Acids

被引：7

作者：

Baltina, L. A., Jr. ^{[1
]}

Fairushina, A. I. ^{[1
]}

Baltina, L. A. ^{[1
]}

Eropkin, M. Yu. ^{[2
]}

Konovalova, N. I. ^{[2
]}

Petrova, P. A. ^{[2
]}

Eropkina, E. M. ^{[2
]}

机构：

[1] Russian Acad Sci, Ufa Inst Chem, 71 Prosp Oktyabrya, Ufa 450054, Russia

[2] Minist Healthcare RF, Res Inst Influenza, 15-17 Prof Popova St, St Petersburg 1987376, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2017年 / 53卷 / 06期

关键词：

glycyrrhizic acid; conjugates; amino acids; synthesis; antiviral activity; DERIVATIVES;

D O I：

10.1007/s10600-017-2209-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Amino-acid conjugates of glycyrrhizic acid (GA) containing phenylalanine, tyrosine, and tryptophan in the carbohydrate and triterpene parts were synthesized using N-hydroxybenzotriazole (HOBt)-N,N'-dicyclohexylcarbodiimide (DCC) and sodium salts of the amino acids. GA conjugates containing two aminoacid residues in the glycoside carbohydrate part were synthesized using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. The GA conjugate with tyrosine exhibited weak but consistent antiviral activity against flu virus A/St.-Petersburg/05/09 (H1N1)pdm09 that was similar to the standard strain A/California/07/09 and pronounced antiviral activity against respiratory-syncytial virus (RSV) and herpes simplex virus (HSV-1).

引用

页码：1096 / 1100

页数：5

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