Synthesis, biological evaluation and in silico studies of tetrazole-heterocycle hybrids

被引：27

作者：

Sribalan, Rajendran ^{[1
]}

Banuppriya, Govindharasu ^{[1
]}

Kirubavathi, Maruthan ^{[1
]}

Padmini, Vediappen ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai 625021, Tamil Nadu, India

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2019年 / 1175卷

关键词：

Hybrid tetrazole; Antimicrobial; Anti-inflammatory; Molecular docking; Molecular orbitals; ANTIBACTERIAL ACTIVITY; MOLECULAR DOCKING; DERIVATIVES;

D O I：

10.1016/j.molstruc.2018.07.114

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The series of three different chemical entities of tetrazole-heterocycle hybrids such as thiophene, pyridine and quinoline tetrazoles were synthesized and characterized for the purpose to develop new lead molecules. Biological evaluations such as in vitro antimicrobial and anti-inflammatory activities were studied. Further, the in silico studies such as Molecular docking (with COX-1, COX-2 and 3TTZ), OFT calculations, the Molecular electrostatic potential (MEP) and ACME were investigated. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：577 / 586

页数：10

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