Synthesis, biological evaluation and in silico studies of tetrazole-heterocycle hybrids

被引：27

作者：

Sribalan, Rajendran ^{[1
]}

Banuppriya, Govindharasu ^{[1
]}

Kirubavathi, Maruthan ^{[1
]}

Padmini, Vediappen ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai 625021, Tamil Nadu, India

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2019年 / 1175卷

关键词：

Hybrid tetrazole; Antimicrobial; Anti-inflammatory; Molecular docking; Molecular orbitals; ANTIBACTERIAL ACTIVITY; MOLECULAR DOCKING; DERIVATIVES;

D O I：

10.1016/j.molstruc.2018.07.114

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The series of three different chemical entities of tetrazole-heterocycle hybrids such as thiophene, pyridine and quinoline tetrazoles were synthesized and characterized for the purpose to develop new lead molecules. Biological evaluations such as in vitro antimicrobial and anti-inflammatory activities were studied. Further, the in silico studies such as Molecular docking (with COX-1, COX-2 and 3TTZ), OFT calculations, the Molecular electrostatic potential (MEP) and ACME were investigated. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：577 / 586

页数：10

共 50 条

[41] Synthesis, characterization, in silico studies and in vitro biological evaluation of isoniazid-hydrazone complexes
Rajan, M. P. Ramya
Rathikha, Ramaswamy
Nithyabalaji, Rajendran
Sribalan, Rajendran
JOURNAL OF MOLECULAR STRUCTURE, 2020, 1216
[42] Synthesis, biological evaluation, molecular docking studies and In-silico ADMET evaluation of pyrazines of pentacyclic triterpenes
Lopez-Huerta, Fabiola A.
Teresa Ramirez-Apan, Maria
Mendez-Cuesta, Carlos A.
Nieto-Camacho, Antonio
Hernandez-Ortega, Simon
Almeida-Aguirre, Ericka K. P.
Cerbon, Marco A.
Delgado, Guillermo
BIOORGANIC CHEMISTRY, 2022, 125
[43] Synthesis, single crystal analysis, biological and docking evaluation of tetrazole derivatives
Aziz, Hamid
Saeed, Aamer
Jabeen, Farukh
Din, Noor Ud
Floerke, Ulrich
HELIYON, 2018, 4 (09):
[44] Design, Synthesis and Biological Evaluation of Triptorelin Analogs Containing Tetrazole Moiety
Sohbati, Hamidreza
Alipour, Mohsen
Hosseinkhani, Saman
Balalaie, Saeed
Hamdan, Fatima
CHEMISTRYSELECT, 2020, 5 (04): : 1443 - 1449
[45] Synthesis and biological evaluation of tetrazole containing compounds as possible anticancer agents
Kumar, Chebolu Naga Sesha Sai Pavan
Parida, Dusmant Kumar
Santhoshi, Amlipur
Kota, Anil Kumar
Sridhar, Balasubramanian
Rao, Vaidya Jayathirtha
MEDCHEMCOMM, 2011, 2 (06) : 486 - 492
[46] Synthesis and biological evaluation of tetrazole fused imidazopyridine derivatives as anticancer agents
Vanam, Narendhar Reddy
Anireddy, Jaya Shree
CHEMICAL DATA COLLECTIONS, 2023, 48
[47] Synthesis of Oxindole Analogues, Biological Activity, and In Silico Studies
Lotfy, Gehad
Aziz, Yasmine M. Abdel
Said, Mohamed M.
El Ashry, El Sayed H.
El Tamany, El Sayed H.
Barakat, Assem
Ghabbour, Hazem A.
Yousuf, Sammer
Ul-Haq, Zaheer
Choudhary, M. Iqbal
CHEMISTRYSELECT, 2019, 4 (35): : 10510 - 10516
[48] Furanchalcone–biphenyl hybrids: synthesis, in silico studies, antitrypanosomal and cytotoxic activities
Elisa García
Rodrigo Ochoa
Isabel Vásquez
Laura Conesa-Milián
Miguel Carda
Andrés Yepes
Iván D. Vélez
Sara M. Robledo
Wilson Cardona-G
Medicinal Chemistry Research, 2019, 28 : 608 - 622
[49] Stereoisomers of oseltamivir - synthesis, in silico prediction and biological evaluation
Hajzer, Viktoria
Fisera, Roman
Latika, Attila
Durmis, Julius
Kollar, Jakub
Frecer, Vladimir
Tucekova, Zuzana
Miertus, Stanislav
Kostolansky, Frantisek
Vareckova, Eva
Sebesta, Radovan
ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 15 (08) : 1828 - 1841
[50] Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids
Danieli, B
Giardini, A
Lesma, G
Passarella, D
Silvani, A
Appendino, G
Noncovich, A
Fontana, G
Bombardelli, E
Sterner, O
CHEMISTRY & BIODIVERSITY, 2004, 1 (02) : 327 - 345

← 1 2 3 4 5 →