Combinatorial Synthesis of 3,5-Dimethylene Substituted 1,2,4-Triazoles

被引：0
|
作者：
Woodard, Scott S. [1 ]
Jerome, Kevin D. [1 ]
机构：
[1] Pfizer Inc, Global Res & Dev, Med & Parallel Chem, Chesterfield, MO 63017 USA
来源：
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2011年 / 14卷 / 02期
关键词：
Cyclizations; combinatorial chemistry; 1,2,4-triazoles; Pinner reaction; hydrazides; imidates; 3,5-DISUBSTITUTED 1,2,4-TRIAZOLES; MIT IMIDSAUREESTERN; ANTIBACTERIAL; CYCLIZATION; ANTAGONISTS; AGENTS; ROUTE;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4-trizoles. [GRAPHICS] .
引用
收藏
页码：132 / 137
页数：6
相关论文
共 50 条
  • [41] 1,2,4-TRIAZOLES .7. METHYLATION OF 1,2,4-TRIAZOLES
    UDA, M
    HISAZUMI, Y
    SATO, K
    KUBOTA, S
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1976, 24 (12) : 3103 - 3108
  • [42] 4(H)-1,2,4-TRIAZOLE DERIVATIVES WITH EXPECTED BIOLOGICAL-ACTIVITY .3. SYNTHESIS OF 4-(CARBOXYPHENYL)-3,5-DIPHENYL-1,2,4-TRIAZOLES, 4-(AMINOPHENYL)-3,5-DIPHENYL-1,2,4-TRIAZOLES, AND 4-PYRIDYL-3,5-DIPHNEYL-1,2,4-TRIAZOLES
    LANGE, J
    TONDYS, H
    POLISH JOURNAL OF PHARMACOLOGY AND PHARMACY, 1975, 27 (02): : 203 - 209
  • [43] SYNTHESIS AND APPLICATION OF TRIAZOLE DERIVATIVES - SYNTHESIS OF 3-ACYL-1,2,4-TRIAZOLES AND 5-ACYL-1,2,4-TRIAZOLES VIA LITHIATION OF 1-ALKYL-1H-1,2,4-TRIAZOLES
    OHTA, S
    KAWASAKI, I
    FUKUNO, A
    YAMASHITA, M
    TADA, T
    KAWABATA, T
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1993, 41 (07) : 1226 - 1231
  • [44] Preparation and Antibacterial Properties of Substituted 1,2,4-Triazoles
    Ledeti, Ionut
    Bercean, Vasile
    Alexa, Anda
    Soica, Codruta
    Suta, Lenuta-Maria
    Dehelean, Cristina
    Trandafirescu, Cristina
    Muntean, Delia
    Licker, Monica
    Fulias, Adriana
    JOURNAL OF CHEMISTRY, 2015, 2015
  • [45] 1,2,4-TRIAZOLES .2. 3-ALKYL-5-ARYL-1,2,4-TRIAZOLES
    LILJEGREN, D
    POTTS, KT
    JOURNAL OF THE CHEMICAL SOCIETY, 1961, (FEB): : 518 - &
  • [46] 1,2,4-TRIAZOLES .3. NEW 1,5-DIARYL-3-(SUBSTITUTED AMINO)-1H-1,2,4-TRIAZOLES AS ANTIINFLAMMATORY AGENTS
    BOZO, E
    SZILAGYI, G
    JANAKY, J
    ARCHIV DER PHARMAZIE, 1989, 322 (10) : 583 - 587
  • [47] SYNTHESIS OF 1,2,4-TRIAZOLES AND 1,2,4-OXADIAZOLES
    LIN, Y
    HLAVKA, JJ
    BITHA, P
    LANG, SA
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1983, 20 (06) : 1693 - 1695
  • [48] Synthesis and structures of 1,2,4-triazoles derivatives
    Wang, Ning
    Sheng, Jun-feng
    Song, Fei
    Tong, Yu-zhu
    Wang, Zuo-xiang
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2015, 85 (03) : 746 - 751
  • [49] SYNTHESIS AND MESOMORPHIC PROPERTIES OF 1-ALKYL-3,5-DIAMINO-1,2,4-TRIAZOLES
    Danilova, E. A.
    Ivolin, A. A.
    Vorontsova, A. A.
    Islyaikin, M. K.
    Anan'eva, G. A.
    Zharnikova, N. V.
    Bykova, V. V.
    Usol'tseva, N. V.
    LIQUID CRYSTALS AND THEIR APPLICATION, 2011, (03): : 5 - 14
  • [50] SYNTHESES OF SUBSTITUTED-1,2,4-TRIAZOLES
    SHAFIEE, A
    NAGHASHIAN, F
    REGHABI, N
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1992, 29 (07) : 1863 - 1865
12345