tert-Butyl 2-{[2,8-bis(trifluoromethyl)-quinolin-4-yl](hydroxy)methyl}-piperidine-1-carboxylate

被引：1

作者：

Goncalves, Raoni S. B. ^{[2
]}

de Souza, Marcus V. N. ^{[2
]}

Wardell, James L. ^{[1
]}

Wardell, Solange M. S. V. ^{[3
]}

Tiekink, Edward R. T. ^{[4
]}

机构：

[1] Fundaco Oswaldo Cruz FIOCRUZ, Ctr Desenvolvimento Tecnol Saude CDTS, BR-21040900 Rio De Janeiro, Brazil

[2] Fundaco Oswaldo Cruz, Inst Tecnol Farmacos Farmanguinhos, BR-21041250 Rio De Janeiro, Brazil

[3] CHEMSOL, Aberdeen AB15 5NY, Scotland

[4] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2011年 / 67卷

关键词：

CRYSTAL-STRUCTURES; MEFLOQUINE; DESIGN;

D O I：

10.1107/S1600536811047726

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The title molecule, C22H24F6N2O3, adopts a folded conformation whereby the carboxylate residue lies over the quinolinyl residue, with the dihedral angle between the carbamate and quinoline planes being 41.64 (7)degrees. Helical supramolecular C(7) chains sustained by O-H center dot center dot center dot O hydrogen bonds propagating along the a-axis direction feature in the crystal packing. The F atoms of one of the CF3 groups are disordered over two orientations; the major component has a site occupancy of 0.824 (7).

引用

页码：O3315 / U163

页数：13

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