Ankylosing spondylitis;
Bone formation;
Bone resorption;
Osteoporosis;
Rheumatoid arthritis;
Vertebral fracture;
BONE-MINERAL DENSITY;
EARLY RHEUMATOID-ARTHRITIS;
NECROSIS-FACTOR-ALPHA;
EARLY ANKYLOSING-SPONDYLITIS;
POPULATION-BASED CONTROLS;
X-RAY ABSORPTIOMETRY;
VERTEBRAL FRACTURES;
BODY-COMPOSITION;
TNF-ALPHA;
POSTMENOPAUSAL WOMEN;
D O I:
10.1007/s00198-010-1319-x
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are two inflammatory joint diseases characterized by bone complications including osteoporosis. In RA, periarticular bone loss, bone erosions, and systemic osteoporosis are observed, with an increased risk of fractures. Determinants of fractures are underlying conditions (as RA has a female preponderance and an increased prevalence with age), severity of the disease, and use of glucocorticoids. However, bone loss can occur even in glucocorticoid-naive patients. Prospective data show that the optimal control of inflammation in RA is associated with decrease in structural damage and bone loss. RA illustrates the role of inflammation on bone resorption. In AS, osteoporosis is an early event and vertebral fracture risk is increased. Bone loss is related mainly to inflammation, as the disease can occur in young male adult populations, and glucocorticoids are not used in this disease. However, AS is characterized by progressive stiffness and ankylosis of the spine and illustrates also the potential role of inflammation on local bone formation.
机构:
Univ Jean Monnet, Univ Lyon, Sainbiose, Unite Inserm 1059, F-42100 St Etienne, France
CHU St Etienne, Hop Nord, Serv Rhumatol, Ave Albert Raimond, F-42100 St Etienne, FranceUniv Jean Monnet, Univ Lyon, Sainbiose, Unite Inserm 1059, F-42100 St Etienne, France
机构:
Klinikum St Georg gGmbH, Med Klin W, Fachbereich Rheumatol, D-04207 Leipzig, GermanyKlinikum St Georg gGmbH, Med Klin W, Fachbereich Rheumatol, D-04207 Leipzig, Germany
Seidel, W.
Scholz, R.
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机构:
Univ Klinikum Leipzig AOR, Orthopad Klin & Poliklin, Leipzig, GermanyKlinikum St Georg gGmbH, Med Klin W, Fachbereich Rheumatol, D-04207 Leipzig, Germany
机构:
Victor Babes Univ Med & Pharmacol, Timisoara, Romania
Timisoara City Univ Emergency Hosp, Clin Lab, Timisoara, RomaniaVictor Babes Univ Med & Pharmacol, Timisoara, Romania
Nemes, D.
Nemes, C.
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机构:
Timisoara Cty Univ Emergency Hosp, Timisoara, RomaniaVictor Babes Univ Med & Pharmacol, Timisoara, Romania
Nemes, C.
Dragoi, M.
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机构:
Victor Babes Univ Med & Pharmacol, Timisoara, Romania
Timisoara City Univ Emergency Hosp, Clin Lab, Timisoara, RomaniaVictor Babes Univ Med & Pharmacol, Timisoara, Romania
Dragoi, M.
Poenaru, D.
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机构:
Timisoara City Univ Emergency Hosp, Clin Lab, Timisoara, RomaniaVictor Babes Univ Med & Pharmacol, Timisoara, Romania
Poenaru, D.
Cretu, O.
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机构:
Timisoara City Univ Emergency Hosp, Clin Lab, Timisoara, RomaniaVictor Babes Univ Med & Pharmacol, Timisoara, Romania
Cretu, O.
Surducan, D.
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机构:
Timisoara City Univ Emergency Hosp, Clin Lab, Timisoara, RomaniaVictor Babes Univ Med & Pharmacol, Timisoara, Romania
Surducan, D.
Popa, D.
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Timisoara City Univ Emergency Hosp, Clin Lab, Timisoara, RomaniaVictor Babes Univ Med & Pharmacol, Timisoara, Romania
Popa, D.
Dragoi, R.
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Timisoara City Univ Emergency Hosp, Clin Lab, Timisoara, RomaniaVictor Babes Univ Med & Pharmacol, Timisoara, Romania
Dragoi, R.
Suciu, O.
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机构:
Timisoara City Univ Emergency Hosp, Clin Lab, Timisoara, RomaniaVictor Babes Univ Med & Pharmacol, Timisoara, Romania
Suciu, O.
Andrei, D.
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机构:
Timisoara City Univ Emergency Hosp, Clin Lab, Timisoara, RomaniaVictor Babes Univ Med & Pharmacol, Timisoara, Romania
机构:
Univ Toronto, Toronto Western Hosp, Res Inst, Arthrit Ctr Excellence, Toronto, ON M5T 2S8, CanadaUniv Toronto, Toronto Western Hosp, Res Inst, Arthrit Ctr Excellence, Toronto, ON M5T 2S8, Canada
Inman, RD
El-Gabalawy, HS
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机构:Univ Toronto, Toronto Western Hosp, Res Inst, Arthrit Ctr Excellence, Toronto, ON M5T 2S8, Canada