Ankylosing spondylitis;
Bone formation;
Bone resorption;
Osteoporosis;
Rheumatoid arthritis;
Vertebral fracture;
BONE-MINERAL DENSITY;
EARLY RHEUMATOID-ARTHRITIS;
NECROSIS-FACTOR-ALPHA;
EARLY ANKYLOSING-SPONDYLITIS;
POPULATION-BASED CONTROLS;
X-RAY ABSORPTIOMETRY;
VERTEBRAL FRACTURES;
BODY-COMPOSITION;
TNF-ALPHA;
POSTMENOPAUSAL WOMEN;
D O I:
10.1007/s00198-010-1319-x
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are two inflammatory joint diseases characterized by bone complications including osteoporosis. In RA, periarticular bone loss, bone erosions, and systemic osteoporosis are observed, with an increased risk of fractures. Determinants of fractures are underlying conditions (as RA has a female preponderance and an increased prevalence with age), severity of the disease, and use of glucocorticoids. However, bone loss can occur even in glucocorticoid-naive patients. Prospective data show that the optimal control of inflammation in RA is associated with decrease in structural damage and bone loss. RA illustrates the role of inflammation on bone resorption. In AS, osteoporosis is an early event and vertebral fracture risk is increased. Bone loss is related mainly to inflammation, as the disease can occur in young male adult populations, and glucocorticoids are not used in this disease. However, AS is characterized by progressive stiffness and ankylosis of the spine and illustrates also the potential role of inflammation on local bone formation.
机构:
Hop Ambroise Pare, AP HP, Serv Rhumatol, 9 Ave Charles de Gaulle, F-92100 Boulogne, France
Univ Paris Diderot, Sorbonne Paris Cite, Lab Excellence, F-75013 Paris, France
Univ Versailles St Quentin, INSERM, U1173, UFR Sci Sante Simone Veil, 2 Ave Source Bievre, F-78180 Montigny Le Bretonneux, FranceHop Ambroise Pare, AP HP, Serv Rhumatol, 9 Ave Charles de Gaulle, F-92100 Boulogne, France
机构:
IRCCS Ist Ortoped Rizzoli, Med & Rheumatol Unit, I-40136 Bologna, ItalyIRCCS Ist Ortoped Rizzoli, Med & Rheumatol Unit, I-40136 Bologna, Italy
Ursini, Francesco
De Giorgi, Alfredo
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机构:
Univ Ferrara, Dept Med Sci, Clin Med Unit, Via L Borsari 47, I-44121 Ferrara, ItalyIRCCS Ist Ortoped Rizzoli, Med & Rheumatol Unit, I-40136 Bologna, Italy
De Giorgi, Alfredo
D'Onghia, Martina
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机构:
IRCCS Ist Ortoped Rizzoli, Med & Rheumatol Unit, I-40136 Bologna, ItalyIRCCS Ist Ortoped Rizzoli, Med & Rheumatol Unit, I-40136 Bologna, Italy
D'Onghia, Martina
De Giorgio, Roberto
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机构:
Univ Ferrara, Dept Translat Med, Internal Med Unit 2, I-44121 Ferrara, ItalyIRCCS Ist Ortoped Rizzoli, Med & Rheumatol Unit, I-40136 Bologna, Italy
De Giorgio, Roberto
Fabbian, Fabio
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机构:
Univ Ferrara, Dept Med Sci, Clin Med Unit, Via L Borsari 47, I-44121 Ferrara, ItalyIRCCS Ist Ortoped Rizzoli, Med & Rheumatol Unit, I-40136 Bologna, Italy
Fabbian, Fabio
Manfredini, Roberto
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机构:
Univ Ferrara, Dept Med Sci, Clin Med Unit, Via L Borsari 47, I-44121 Ferrara, ItalyIRCCS Ist Ortoped Rizzoli, Med & Rheumatol Unit, I-40136 Bologna, Italy