Stereospecific displacement of 1-(pyridinyl)ethanols with amines and thiols via methanesulfonate esters;: Asymmetric synthesis of 1-(pyridinyl)-ethylamines and sulfides

被引：0
|
作者：
Uenishi, J
Takagi, T
Ueno, T
Hiraoka, T
Yonemitsu, O
Tsukube, H
机构：
[1] Okayama Univ Sci, Dept Chem, Okayama 7000005, Japan
[2] Osaka City Univ, Grad Sch Sci, Dept Chem, Sumiyoshi Ku, Osaka 5588585, Japan
来源：
SYNLETT | 1999年 / 01期
关键词：
stereospecific substitution; chiral (pyridinyl)ethylamine; chiral (pyridinyl)ethylsulfide; chiral ligand; anti-AIDS drug;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Stereospecific reaction of optically pure (S)-1-(2-pyridinyl) ethanol methanesulfonate with aromatic and aliphatic amines, and thiols in DMSO gives (R)-1-(2-pyridinyl)ethylamine and sulfide with inversion of the configuration in good yields.
引用
收藏
页码：41 / 44
页数：4
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