Stereospecific displacement of 1-(pyridinyl)ethanols with amines and thiols via methanesulfonate esters;: Asymmetric synthesis of 1-(pyridinyl)-ethylamines and sulfides

被引：0

作者：

Uenishi, J

Takagi, T

Ueno, T

Hiraoka, T

Yonemitsu, O

Tsukube, H

机构：

[1] Okayama Univ Sci, Dept Chem, Okayama 7000005, Japan

[2] Osaka City Univ, Grad Sch Sci, Dept Chem, Sumiyoshi Ku, Osaka 5588585, Japan

来源：

SYNLETT | 1999年 / 01期

关键词：

stereospecific substitution; chiral (pyridinyl)ethylamine; chiral (pyridinyl)ethylsulfide; chiral ligand; anti-AIDS drug;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereospecific reaction of optically pure (S)-1-(2-pyridinyl) ethanol methanesulfonate with aromatic and aliphatic amines, and thiols in DMSO gives (R)-1-(2-pyridinyl)ethylamine and sulfide with inversion of the configuration in good yields.

引用

页码：41 / 44

页数：4

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