(+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble

被引：14
|
作者：
Mollataghi, Abbas [1 ]
Hadi, A. Hamid A. [1 ]
Awang, Khalijah [1 ]
Mohamad, Jamaludin [2 ]
Litaudon, Marc [3 ]
Mukhtar, Mat Ropi [1 ]
机构：
[1] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia
[2] Univ Malaya, Fac Sci, Inst Biol Sci, Kuala Lumpur 50603, Malaysia
[3] CNRS, Inst Chim Subst Nat, Ctr Rech Gif, F-91198 Gif Sur Yvette, France
来源：
MOLECULES | 2011年 / 16卷 / 08期
关键词：
Beilschmiedia kunstleri; alkaloid; neolignan; lauraceae; antioxidant; ENDIANDRIC ACID ANALOGS; APORPHINE ALKALOIDS; LAURACEAE; ERYTHROPHLOIA; STYRYLPYRONES; FLAVONOIDS; OIL;
D O I：
10.3390/molecules16086582
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new neolignan, 3,4-dimethoxy-3',4'-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6) and (-)-pallidine (7), were isolated from the leaves of Beilschmiedia kunstleri. The structures were established through various spectroscopic methods notably 1D- and 2D-NMR, UV, IR and LCMS-IT-TOF. (+)-Kunstlerone (1) showed a strong antioxidant activity, with an SC50 of 20.0 mu g/mL.
引用
下载
收藏
页码：6582 / 6590
页数：9
相关论文
共 50 条
  • [1] (-)-Kunstleramide, a New Antioxidant and Cytotoxic Dienamide from the Bark of Beilschmiedia kunstleri Gamble
    Mollataghi, Abbas
    Hadi, A. Hamid A.
    Cheah, Shiau-Chuen
    MOLECULES, 2012, 17 (04): : 4197 - 4208
  • [2] Callignan A, A New Neolignan from the Leaves of Callicarpa kwangtungensis
    Ren, Hancheng
    Fei, Weiqiang
    RECORDS OF NATURAL PRODUCTS, 2023, 17 (05) : 947 - 951
  • [3] A new neolignan glycoside from the leaves of Acer truncatum
    Dong, Lang-Ping
    Ni, Wei
    Dong, Jin-Yang
    Li, Jun-Zhu
    Chen, Chang-Xiang
    Liu, Hai-Yang
    MOLECULES, 2006, 11 (12) : 1009 - 1014
  • [4] A new neolignan and antioxidant Phenols from Nectandra grandiflora
    Ribeiro, AB
    Bolzani, VD
    Yoshida, M
    Santos, LS
    Eberlin, MN
    Silva, DHS
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2005, 16 (3B) : 526 - 530
  • [5] Two new neolignan glycosides from leaves of Osmanthus heterophyllus
    Machida, Koichi
    Sakamoto, Shigeaki
    Kikuchi, Masao
    JOURNAL OF NATURAL MEDICINES, 2009, 63 (02) : 227 - 231
  • [6] Two new neolignan glycosides from leaves of Osmanthus heterophyllus
    Koichi Machida
    Shigeaki Sakamoto
    Masao Kikuchi
    Journal of Natural Medicines, 2009, 63
  • [7] Antioxidant activities of a new lignan and a neolignan from Saururus chinensis
    Lee, WS
    Baek, YI
    Kim, JR
    Cho, KH
    Sok, DE
    Jeong, TS
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (22) : 5623 - 5628
  • [8] A new neolignan and a new biphenylpropanoid from the leaves of Cupressus funebris Endl.
    Zhong, Si-Yu
    Jiang, Hong-Yu
    Wu, Li-Ping
    Liu, Meng-Ying
    Yu, Ya-Rui
    Li, Cheng-Rong
    Huang, Jing
    SOUTH AFRICAN JOURNAL OF BOTANY, 2021, 139 : 140 - 147
  • [9] A New Biphenyl Neolignan from Leaves of Patrinia villosa (Thunb.) Juss.
    Yan Xin-Jia
    Wei, Liu
    Ying, Zhao
    Ning, Chen
    Ying, Xu
    Jian, Wu
    Tan, Wang
    Yue, Li
    Zheng, Xiang
    PHARMACOGNOSY MAGAZINE, 2016, 12 (45) : 1 - 3
  • [10] Neolignan and megastigmane glycosides from the leaves of Pterospermum semisagittatum
    Khan, MSH
    Nahar, N
    Mosihuzzaman, M
    Rashid, MA
    PHARMAZIE, 2005, 60 (01): : 72 - 74
12345