(+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble

被引：14

作者：

Mollataghi, Abbas ^{[1
]}

Hadi, A. Hamid A. ^{[1
]}

Awang, Khalijah ^{[1
]}

Mohamad, Jamaludin ^{[2
]}

Litaudon, Marc ^{[3
]}

Mukhtar, Mat Ropi ^{[1
]}

机构：

[1] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Fac Sci, Inst Biol Sci, Kuala Lumpur 50603, Malaysia

[3] CNRS, Inst Chim Subst Nat, Ctr Rech Gif, F-91198 Gif Sur Yvette, France

来源：

MOLECULES | 2011年 / 16卷 / 08期

关键词：

Beilschmiedia kunstleri; alkaloid; neolignan; lauraceae; antioxidant; ENDIANDRIC ACID ANALOGS; APORPHINE ALKALOIDS; LAURACEAE; ERYTHROPHLOIA; STYRYLPYRONES; FLAVONOIDS; OIL;

D O I：

10.3390/molecules16086582

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new neolignan, 3,4-dimethoxy-3',4'-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6) and (-)-pallidine (7), were isolated from the leaves of Beilschmiedia kunstleri. The structures were established through various spectroscopic methods notably 1D- and 2D-NMR, UV, IR and LCMS-IT-TOF. (+)-Kunstlerone (1) showed a strong antioxidant activity, with an SC50 of 20.0 mu g/mL.

引用

页码：6582 / 6590

页数：9

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