A dual-site two-photon fluorescent probe for visualizing mitochondrial aminothiols in living cells and mouse liver tissues

被引：20
|
作者：
Meng, Fangfang [1 ]
Liu, Yong [1 ]
Yu, Xiaoqiang [2 ]
Lin, Weiying [1 ]
机构：
[1] Univ Jinan, Inst Fluorescent Probes Biol Imaging, Sch Chem & Chem Engn, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China
[2] Shandong Univ, State Key Lab Crystal Mat, Ctr Bio & Micro Nano Funct Mat, Jinan 250100, Peoples R China
来源：
NEW JOURNAL OF CHEMISTRY | 2016年 / 40卷 / 09期
关键词：
AIE LUMINOGEN; HOMOCYSTEINE; GLUTATHIONE; DERIVATIVES; TRACKING; CYSTEINE; ACID;
D O I：
10.1039/c6nj00330c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Thiol-containing amino acids ( RSH) play a key role in maintaining the redox environment. In this work, we developed a novel dual-site two-photon ( TP) fluorescent RSH probe ( CA-TPP) for imaging mitochondrial RSH in living cells and mouse liver tissues. This probe exhibited rapid response and high TP photostability towards mitochondrial RSH. In particular, probe CA-TPP was capable of using TP fluorescence to track mitochondrial RSH over a long period.
引用
收藏
页码：7399 / 7406
页数：8
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