MicroRNAs in central nervous system diseases: A prospective role in regulating blood-brain barrier integrity

被引：61
|
作者：
Ma, Feifei [1 ]
Zhang, Xuejing [1 ]
Yin, Ke-Jie [1 ,2 ]
机构：
[1] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh Inst Brain Disorders & Recovery, 200 Lothrop St,BST 5514, Pittsburgh, PA 15213 USA
[2] Vet Affairs Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA 15261 USA
来源：
EXPERIMENTAL NEUROLOGY | 2020年 / 323卷
基金：
美国国家卫生研究院;
关键词：
MicroRNAs; Central nervous system diseases; Blood-brain barrier; Vascular integrity; TUMOR BARRIER; CEREBRAL-ISCHEMIA; TIGHT JUNCTIONS; INTRACEREBRAL HEMORRHAGE; EXPRESSION CHANGES; STROKE OUTCOMES; IN-VITRO; PERMEABILITY; DYSFUNCTION; DISRUPTION;
D O I：
10.1016/j.expneurol.2019.113094
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Given the essential role of the blood-brain barrier (BBB) in the central nervous system (CNS), cumulative investigations have been performed to elucidate how modulation of BBB structural and functional integrity affects the pathogenesis of CNS diseases such as stroke, traumatic brain injuries, dementia, and cerebral infection. Recent studies have demonstrated that microRNAs (miRNAs) contribute to the maintenance of the BBB and thereby mediate CNS homeostasis. This review summarizes emerging studies that demonstrate cerebral miRNAs regulate BBB function in CNS disorders, emphasizing the direct role of miRNAs in BBB molecular composition. Evidence presented in this review will encourage a deeper understanding of the mechanisms by which miRNAs regulate BBB function, and facilitate the development of new miRNAs-based therapies in patients with CNS diseases.
引用
收藏
页数：11
相关论文
共 50 条
  • [31] Flavonoids and the brain: Interactions at the blood-brain barrier and their physiological effects on the central nervous system
    Youdim, KA
    Shukitt-Hale, B
    Joseph, JA
    FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (11) : 1683 - 1693
  • [32] BLOOD-BRAIN BARRIER AND GROUND SUBSTANCE OF CENTRAL NERVOUS SYSTEM - EFFECT OF BRAIN WOUNDS
    HESS, A
    ARCHIVES OF NEUROLOGY AND PSYCHIATRY, 1955, 74 (AUG): : 149 - 157
  • [33] Blood-brain barrier integrity
    Fehervari, Zoltan
    NATURE IMMUNOLOGY, 2019, 20 (01) : 1 - 1
  • [34] Role of efflux transport across the blood-brain barrier and blood cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system
    Suzuki, H
    Terasaki, T
    Sugiyama, Y
    ADVANCED DRUG DELIVERY REVIEWS, 1997, 25 (2-3) : 257 - 285
  • [35] PERMEABILITY OF BLOOD-BRAIN BARRIER IN AN ALTERED FUNCTIONAL STATE OF CENTRAL NERVOUS SYSTEM
    MAIZELIS, MY
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE,USSR, 1965, 60 (10): : 1131 - &
  • [36] Utilization of nanotechnology to surmount the blood-brain barrier in disorders of the central nervous system
    Luo, Qian
    Yang, Jiaying
    Yang, Mei
    Wang, Yingtong
    Liu, Yiran
    Liu, Jixuan
    Kalvakolanu, Dhan, V
    Cong, Xianling
    Zhang, Jinnan
    Zhang, Ling
    Guo, Baofeng
    Duo, Yanhong
    MATERIALS TODAY BIO, 2025, 31
  • [37] Regulation of the Blood-Brain Barrier: New Treatments for Central Nervous System Neoplasms
    Kalra, Ricky
    Couldwell, William T.
    WORLD NEUROSURGERY, 2011, 75 (02) : 179 - 180
  • [38] The blood-brain barrier: Principles for targeting peptides and drugs to the central nervous system
    Begley, DJ
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 1996, 48 (02) : 136 - 146
  • [39] BLOOD-BRAIN BARRIER AND GROUND SUBSTANCE OF CENTRAL NERVOUS SYSTEM - SIMILARITIES IN DEVELOPMENT
    HESS, A
    ARCHIVES OF NEUROLOGY AND PSYCHIATRY, 1955, 73 (APR): : 380 - 386
  • [40] Glucocorticoid signalling and resistance at the blood-brain barrier in central nervous system disorders
    Kleinschnitz, Christoph
    Blecharz, Kinga
    Kahles, Timo
    Schwarz, Tobias
    Kraft, Peter
    Goebel, Kerstin
    Meuth, Sven G.
    Burek, Malgorzata
    Tha, Serge
    Scheffer, David
    Thum, Thomas
    Stoll, Guido
    Foerster, Carola
    VASCULAR PHARMACOLOGY, 2012, 56 (5-6) : 355 - 355
12345