Can Broadly Neutralizing HIV-1 Antibodies Help Achieve an ART-Free Remission?

被引：23
|
作者：
Hsu, Denise C. C. [1 ,2 ]
Mellors, John W. W. [3 ]
Vasan, Sandhya [1 ,2 ]
机构：
[1] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA
[2] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20814 USA
[3] Univ Pittsburgh, Dept Med, Div Infect Dis, Pittsburgh, PA 15212 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
基金：
比尔及梅琳达.盖茨基金会;
关键词：
broadly neutralizing HIV-1 antibody; HIV remission; HIV cure; HIV immunotherapy; HIV therapeutics; ANTIRETROVIRAL THERAPY; IMPROVES PROTECTION; INFECTION; RESERVOIR; IDENTIFICATION; INDIVIDUALS; MORTALITY; POTENCY; BREADTH; VIREMIA;
D O I：
10.3389/fimmu.2021.710044
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Many broadly neutralizing antibodies (bnAbs) targeting the HIV-1 envelope glycoprotein are being assessed in clinical trials as strategies for HIV-1 prevention, treatment, and antiretroviral-free remission. BnAbs can neutralize HIV-1 and target infected cells for elimination. Concerns about HIV-1 resistance to single bnAbs have led to studies of bnAb combinations with non-overlapping resistance profiles. This review focuses on the potential for bnAbs to induce HIV-1 remission, either alone or in combination with latency reversing agents, therapeutic vaccines or other novel therapeutics. Key topics include preliminary activity of bnAbs in preclinical models and in human studies of HIV-1 remission, clinical trial designs, and antibody design strategies to optimize pharmacokinetics, coverage of rebound-competent virus, and enhancement of cellular immune functions.
引用
收藏
页数：11
相关论文
共 50 条
  • [31] Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies
    Haynes, BF
    Fleming, J
    St Clair, EW
    Katinger, H
    Stiegler, G
    Kunert, R
    Robinson, J
    Scearce, RM
    Plonk, K
    Staats, HF
    Ortel, TL
    Liao, HX
    Alam, SM
    SCIENCE, 2005, 308 (5730) : 1906 - 1908
  • [32] Broadly neutralizing antibodies and vaccine design against HIV-1 infection
    Qian Wang
    Linqi Zhang
    Frontiers of Medicine, 2020, 14 : 30 - 42
  • [33] HIV-1 cell-to-cell transmission and broadly neutralizing antibodies
    Dufloo, Jeremy
    Bruel, Timothee
    Schwartz, Olivier
    RETROVIROLOGY, 2018, 15
  • [34] FOCUS ON RESEARCH Broadly Neutralizing Antibodies for HIV-1 Prevention or Immunotherapy
    Caskey, Marina
    Klein, Florian
    Nussenzweig, Michel C.
    NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (21): : 2019 - 2021
  • [35] HIV-1 envelope glycoprotein immunogens to induce broadly neutralizing antibodies
    Sliepen, Kwinten
    Sanders, Rogier W.
    EXPERT REVIEW OF VACCINES, 2016, 15 (03) : 349 - 365
  • [36] Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers
    Elise Landais
    Penny L. Moore
    Retrovirology, 15
  • [37] Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning
    Peter D. Kwong
    John R. Mascola
    Gary J. Nabel
    Nature Reviews Immunology, 2013, 13 : 693 - 701
  • [38] Phage display as a tool for identifying HIV-1 broadly neutralizing antibodies
    Chikaev, A. N.
    Rudometov, A. P.
    Merkulyeva, Yu A.
    Karpenko, L., I
    VAVILOVSKII ZHURNAL GENETIKI I SELEKTSII, 2021, 25 (05): : 562 - 572
  • [39] Rational Design of Vaccines to Elicit Broadly Neutralizing Antibodies to HIV-1
    Kwong, Peter D.
    Mascola, John R.
    Nabel, Gary J.
    COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2011, 1 (01):
  • [40] Lessons from babies: inducing HIV-1 broadly neutralizing antibodies
    Tomaras, Georgia D.
    Haynes, Barton F.
    NATURE MEDICINE, 2014, 20 (06) : 583 - 585
12345