Can Broadly Neutralizing HIV-1 Antibodies Help Achieve an ART-Free Remission?

被引：23

作者：

Hsu, Denise C. C. ^{[1
,2
]}

Mellors, John W. W. ^{[3
]}

Vasan, Sandhya ^{[1
,2
]}

机构：

[1] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA

[2] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20814 USA

[3] Univ Pittsburgh, Dept Med, Div Infect Dis, Pittsburgh, PA 15212 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

基金：

比尔及梅琳达.盖茨基金会;

关键词：

broadly neutralizing HIV-1 antibody; HIV remission; HIV cure; HIV immunotherapy; HIV therapeutics; ANTIRETROVIRAL THERAPY; IMPROVES PROTECTION; INFECTION; RESERVOIR; IDENTIFICATION; INDIVIDUALS; MORTALITY; POTENCY; BREADTH; VIREMIA;

D O I：

10.3389/fimmu.2021.710044

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many broadly neutralizing antibodies (bnAbs) targeting the HIV-1 envelope glycoprotein are being assessed in clinical trials as strategies for HIV-1 prevention, treatment, and antiretroviral-free remission. BnAbs can neutralize HIV-1 and target infected cells for elimination. Concerns about HIV-1 resistance to single bnAbs have led to studies of bnAb combinations with non-overlapping resistance profiles. This review focuses on the potential for bnAbs to induce HIV-1 remission, either alone or in combination with latency reversing agents, therapeutic vaccines or other novel therapeutics. Key topics include preliminary activity of bnAbs in preclinical models and in human studies of HIV-1 remission, clinical trial designs, and antibody design strategies to optimize pharmacokinetics, coverage of rebound-competent virus, and enhancement of cellular immune functions.

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页数：11

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