Molecularly imprinted polymer combinatorial libraries for multiple simultaneous chiral separations

We demonstrate that the ligand cross-reactivities of molecularly imprinted polymers can be beneficially employed for the simultaneous separation of different stereoisomeric structures. In this study, a limited molecularly imprinted polymer combinatorial library has been prepared and used for the simultaneous separation of a mixture of N-tert-butyloxycarbonyl-L-phenylalanine, N-tert-butyloxycarbonyl-D-phenylalanine N-acetyl-L-phenylalaninyl-L-tryptophanyl methyl ester, N-acetyl-D-phenylalaninyl-D-tryptophanyl methyl ester, yohimbine and corynanthine.