A continuous-flow mass biosensor for the real-time dynamic analysis of protease inhibition

被引：7

作者：

Huang, Yanyan ^{[1
]}

Zhang, Qundan ^{[1
]}

Liu, Guoquan ^{[1
]}

Zhao, Rui ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 30期

基金：

中国国家自然科学基金;

关键词：

QUARTZ-CRYSTAL MICROBALANCE; TURN-ON ASSAY; HUMAN SERUM; TRYPSIN; SURFACE; IMMOBILIZATION; CELLS; RECOGNITION; SUBSTRATE; RESONANCE;

D O I：

10.1039/c5cc00885a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A flow injection analysis-quartz crystal microbalance (FIA-QCM) biosensor was developed for probing the dynamic interactions during protease inhibition. Being sensitive to conformation features of different proteases, this continuous-flow sensor has potential for structural-functional analysis and inhibitor selection.

引用

页码：6601 / 6604

页数：4

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