Superparamagnetic graphene quantum dot as a dual-modality contrast agent for confocal fluorescence microscopy and magnetomotive optical coherence tomography

被引：9
|
作者：
Li, Wei [1 ]
Song, Wenxing [2 ]
Chen, Biqiong [3 ]
Matcher, Stephen J. [1 ]
机构：
[1] Univ Sheffield, Dept Elect & Elect Engn, Broad Lane, Sheffield S3 7HQ, S Yorkshire, England
[2] Univ Sheffield, Dept Chem & Biol Engn, Sheffield, S Yorkshire, England
[3] Queens Univ Belfast, Sch Mech & Aerosp Engn, Belfast, Antrim, North Ireland
来源：
JOURNAL OF BIOPHOTONICS | 2019年 / 12卷 / 02期
基金：
英国工程与自然科学研究理事会;
关键词：
contrast agent; fluorescence microscopy; graphene; magnetomotive optical coherence tomography; quantum dot; IRON-OXIDE NANOPARTICLES; CELL-BASED THERAPY; DRUG-DELIVERY; STEM-CELLS; NANOCRYSTALS; DISEASE; BLUE; SIZE;
D O I：
10.1002/jbio.201800219
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A magnetic graphene quantum dot (MGQD) nanoparticle, synthesized by hydrothermally reducing and cutting graphene oxide-iron oxide sheet, was demonstrated to possess the capabilities of simultaneous confocal fluorescence and magnetomotive optical coherence tomography (MMOCT) imaging. This MGQD shows low toxicity, significant tunable blue fluorescence and superparamagnetism, which can thus be used as a dual-modality contrast agent for confocal fluorescence microscopy (CFM) and MMOCT. The feasibility of applying MGQD as a tracer of cells is shown by imaging and visualizing MGQD labeled cells using CFM and our in-house MMOCT. Since MMOCT and CFM can offer anatomical structure and intracellular details, respectively, the MGQD for cell tracking could provide a more comprehensive diagnosis.
引用
收藏
页数：11
相关论文
共 50 条
  • [1] DUAL-MODALITY FLUORESCENCE/MICRO-OPTICAL COHERENCE TOMOGRAPHY
    Ford, T. N.
    Chu, K. K.
    Birket, S. E.
    Solomon, G. M.
    Mazur, M.
    Rowe, S. M.
    Tearney, G. J.
    PEDIATRIC PULMONOLOGY, 2014, 49 : 248 - 248
  • [2] A dual modality fluorescence confocal and optical coherence tomography microendoscope
    Makhlouf, Houssine
    Rouse, Andrew R.
    Gmitro, Arthur F.
    ENDOSCOPIC MICROSCOPY V, 2010, 7558
  • [3] Dual-modality optical coherence tomography and fluorescence tethered capsule endomicroscopy
    Wartak, Andreas
    Kelada, Alfred K.
    Alarcon, Paola A. Leon
    Bablouzian, Ara L.
    Ahsen, Osman O.
    Gregg, Abigail L.
    Wei, Yuxiao
    Bollavaram, Keval
    Sheil, Conor J.
    Farewell, Edward
    VanTol, Schuyler
    Smith, Rachel
    Grahmann, Patricia
    Baillargeon, Aaron R.
    Gardecki, Joseph A.
    Tearney, Guillermo J.
    BIOMEDICAL OPTICS EXPRESS, 2021, 12 (07): : 4308 - 4323
  • [4] A dual-modality optical coherence tomography and fluorescence lifetime imaging microscopy system for simultaneous morphological and biochemical tissue characterization
    Park, Jesung
    Jo, Javier A.
    Shrestha, Sebina
    Pande, Paritosh
    Wan, Qiujie
    Applegate, Brian E.
    BIOMEDICAL OPTICS EXPRESS, 2010, 1 (01): : 186 - 200
  • [5] Optical coherence tomography and fluorescence microscopy dual-modality imaging for in vivo single-cell tracking with nanowire lasers
    Li, Xuzhou
    Zhang, Wei
    Wang, William Y.
    Wu, Xiaoqin
    Li, Yanxiu
    Tan, Xiaotian
    Matera, Daniel L.
    Baker, Brendon M.
    Paulus, Yannis M.
    Fan, Xudong
    Wang, Xueding
    BIOMEDICAL OPTICS EXPRESS, 2020, 11 (07) : 3659 - 3672
  • [6] Dual modality fluorescence confocal and spectral-domain optical coherence tomography microendoscope
    Makhlouf, Houssine
    Rouse, Andrew R.
    Gmitro, Arthur F.
    BIOMEDICAL OPTICS EXPRESS, 2011, 2 (03): : 634 - 644
  • [7] Dual-modality fluorescence and full-field optical coherence microscopy for biomedical imaging applications
    Auksorius, Egidijus
    Bromberg, Yaron
    Motiejuenaite, Rueta
    Pieretti, Alberto
    Liu, Linbo
    Coron, Emmanuel
    Aranda, Jorge
    Goldstein, Allan M.
    Bouma, Brett E.
    Kazlauskas, Andrius
    Tearney, Guillermo J.
    BIOMEDICAL OPTICS EXPRESS, 2012, 3 (03): : 661 - 666
  • [8] RGD coated protein microspheres as a dual fluorescent and magnetomotive contrast agent for targeted cancer imaging with magnetomotive optical coherence tomography
    Nguyen, Freddy T.
    John, Renu
    Chaney, Eric J.
    Dibbern, Elizabeth M.
    Suslick, Kenneth S.
    Boppart, Stephen A.
    CANCER RESEARCH, 2010, 70
  • [9] Novel magnetic graphene quantum dot as dual modality fluorescence/MMOCT contrast agent for tracking epithelial stem cells
    Li, Wei
    Matcher, Stephen J.
    REPORTERS, MARKERS, DYES, NANOPARTICLES, AND MOLECULAR PROBES FOR BIOMEDICAL APPLICATIONS IX, 2017, 10079
  • [10] Dual-coil magnetomotive optical coherence tomography for contrast enhancement in liquids
    Kim, Jongsik
    Ahmad, Adeel
    Boppart, Stephen A.
    OPTICS EXPRESS, 2013, 21 (06): : 7139 - 7147
12345